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Not yet recruiting NCT07158125

Pathogenesis of Periodontal Disease in Individuals With Psoriasis

— Observational Psoriasis

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
This is an observational study: the protocol does not assign a study treatment.
Who it may be relevant to
Registry conditions: Psoriasis. Basic parameters: 18 years — 65 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Turkey (Türkiye)
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Role of Th17 and Stress-related Neuroendocrine Markers in the Pathogenesis of Periodontal Disease in Individuals With Psoriasis

Overview

The aim of this study is to evaluate the levels of Th17 cell-associated cytokines (IL-17, IL-21, IL-23) and the salivary stress biomarkers cortisol, dehydroepiandrosterone, and Chromogranin A in the pathogenesis of periodontal disease in individuals with psoriasis, thereby revealing immunological and neuroendocrine interactions. The fundamental question it aims to answer is: What are the biological mechanisms that may increase the risk of periodontal disease in individuals with psoriasis? In this context, the periodontal status of individuals with psoriasis will be clinically assessed, followed by analysis of the levels of Th17-associated cytokines and stress biomarkers in gingival crevicular fluid and saliva samples. Additionally, patients will be asked questions from the Social Appearance Anxiety Scale. The periodontal status of individuals with psoriasis will be determined cross-sectionally, and the resulting biomarker levels will be examined. In addition, the data obtained will be evaluated with statistical analysis in relation to disease severity and clinical parameters.

Detailed description

Psoriasis and periodontitis are chronic inflammatory diseases, and Th17 cells and their secreted cytokines, such as IL-17, IL-21, and IL-23, have been shown to play a significant role in the pathogenesis of both. Recent studies suggest a possible immunological link between these two diseases. Furthermore, in a stress-induced disease like psoriasis, the effects of chronic stress on the immune system are attracting increasing attention. The interaction of neuroendocrine markers, such as cortisol, dehydroepiandrosterone (DHEA), and chromogranin A (CgA), released via the hypothalamic-pituitary-adrenal axis, with immune responses and inflammatory processes may play a significant role in the development of periodontal disease.

This project will jointly examine the immunological and neuroendocrine basis of periodontal disease in individuals with psoriasis. Cortisol, DHEA, and CgA levels will be measured in saliva samples, and the relationship between these biomarkers and periodontal parameters will be analyzed. Cytokine levels related to the Th17 pathways will be examined in gingival crevicular fluid to reveal the impact of psoriasis on periodontal tissue. The Social Appearance Anxiety Scale will also be administered. All data obtained will be statistically analyzed.

In this context, this study aims to investigate the role of these two chronic and inflammatory diseases (periodontitis and psoriasis) in the Th17 axis based on stress biomarkers (IL-17, IL-21, and IL-23). Thus, we plan to evaluate the relationship between periodontitis and psoriasis biochemically using salivary stress markers (cortisol, DHEA, and CgA) and to evaluate the immunopathogenesis of Th17.

The findings of this study may significantly contribute to clinical practice regarding the early diagnosis and management of periodontal disease in individuals with psoriasis. It also aims to encourage multidisciplinary approaches by providing a holistic understanding of the effects of stress on the immune system and periodontal health.

Primary outcome measures

  • Gingival Crevicular Fluid (GCF) Collection [Time frame: Day 1]
  • Saliva sampling [Time frame: Day 1]
  • Clinical Periodontal Parameters (Plaque Index) [Time frame: Day 1]
  • Clinical Periodontal Parameters (Gingival Index) [Time frame: Day 1]
  • Periodontal Clinical Parametres (Bleeding on Probing Index) [Time frame: Day 1]
  • Periodontal Clinical Parametres (Probing Pocket Depth) [Time frame: Day 1]
  • Periodontal Clinical Parametres (Clinical Attachment Loss) [Time frame: Day 1]
  • Application of the Social Appearance Anxiety Scale [Time frame: Day 1]
Secondary outcome measures (1)
  • Analysis of cortisol, dehidroepiandrosteron (DHEA) and chromogranin A [Time frame: 5th month]

Eligibility criteria

Inclusion criteria

  • Being between the ages of 18 and 65
  • Being diagnosed with psoriasis by a dermatologist
  • Having at least 20 teeth
  • Not having received periodontal treatment in the last 6 months
  • Not having taken antibiotics, steroids, and/or nonsteroidal anti-inflammatory drugs in the last 3 weeks
  • Not having any autoimmune disease, osteoporosis, or cancer
  • Not using immunosuppressive drugs, oral contraceptives, or bisphosphonates
  • Not being pregnant
  • Not having an active infectious disease (acute hepatitis, tuberculosis, AIDS)
  • Not using chronic medications that affect periodontal tissues (cyclosporine A, phenytoin)
  • Not having taken antioxidant supplements in the last 6 months

Exclusion criteria

  • <20 teeth
  • Any significant oral infection (i.e., herpes or candidiasis)
  • Oral injuries or bleeding unrelated to periodontitis
  • Periodontal therapy and antibiotic therapy within the past 3 months
  • Salivary gland dysfunction
  • Acute illness (fever, sore throat)
  • Systemic illness, mental illness, immunosuppressive drugs or immunodeficiency
  • Pregnancy or breastfeeding
  • Use of antidepressants

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Case-only

Study locations

Turkey (Türkiye) · 1 center
  • Department of Periodontology of the Faculty of Dentistry of Recep Tayyip Erdogan Universit — Rize

Identifiers

NCT: NCT07158125 · periopsoriasis06/2025

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗