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Recruiting NCT07145047

Clinical Study of Oncolytic Virus in Glioblastoma

Phase I / Phase II Interventional Glioblastoma (GBM)

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: oncolytic virus.
Who it may be relevant to
Registry conditions: Glioblastoma (GBM). Basic parameters: 18 years — 70 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
China
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Clinical Study on the Application of Oncolytic Virus in Recurrent Glioblastoma

Overview

This clinical trial aims to evaluate whether an oncolytic viral agent can treat recurrent glioblastoma. It will also assess the safety and tolerability of the oncolytic viral agent. The primary question it seeks to answer is: What medical problems do participants experience when injected with the oncolytic viral agent? Researchers will administer the oncolytic viral agent via intratumoral injection to determine its efficacy in treating recurrent glioblastoma. Participant Procedures: Receive the initial injection, followed by additional injections every 2-4 weeks for a total of 6 injections. Undergo physical examinations and tests every 2 to 4 weeks. Record their symptoms, hematological test results, and imaging findings.

Interventions

  • Biological oncolytic virus
    Intratumoral injection of oncolytic virus.

Primary outcome measures

  • Maximum tolerated dose [Time frame: 4 hours, 2 days, 7 days and 14 days after administration]

Eligibility criteria

Inclusion criteria

  • Patients with recurrent glioblastoma, for whom the standard methods of treatment are considered ineffective by the medical commission.
  • Histologically confirmed recurrent glioblastoma.
  • Magnetic resonance imaging (MRI) showed that the maximum diameter of recurrent lesions is greater than 1.0 cm.
  • Before inclusion of patients in the study, at least one of the following types of therapy was previously performed: 4.1 Time from the last radiotherapy/surgery is more than 28 days; 4.2 Subjects maintained stable or declining for at least 7 days prior to corticosteroid regimen; 4.3 Most recent antitumor therapy must have been completed within the specified time prior to treatment: vincristine 2 weeks, nitrosoureas 4 weeks, bevacizumab 4 weeks, temozolomide 6 weeks.
  • Age >=18 years, <=70 years.
  • Hematological indicators, kidney and liver function are normal.
  • The subjects must agree to the use of an acceptable contraceptive method throughout the study, from the time informed consent is provided to 180 days after receiving treatment.
  • Patient's ability to perform the study procedure and provide written informed consent in accordance with the GCP and local laws.

Exclusion criteria

  • Incompatibility of patients with the inclusion criteria mentioned above.
  • Participated in other drug clinical trials within 4 weeks
  • Preoperative bleeding susceptibility or use of anticoagulants or any medication that may increase the risk of bleeding.
  • Patients with extracranial metastases.
  • Have poorly controlled clinical diseases, such as liver aminotransferase (aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT)) or total bilirubin > 2 times the upper normal limit.
  • Female subjects: during pregnancy or lactation.
  • Uncontrolled active infection, unstable or severe concomitant disease of infection. Patients with immunodeficiency, autoimmune diseases, active HBV infection, HCV infection, or active HIV infection.
  • Patients with a history of psychotropic substance abuse who are unable to quit or with mental disorders.
  • Subjects had any active autoimmune disease or a history of autoimmune disease.
  • Has a history of antiviral drug use within 1 week.
  • Subjects are receiving immunosuppressive therapy, or concurrent chemotherapy, or radiation, or biotherapy.
  • There are prohibited items for MRI, such as: pacemakers, epicardial pacemaker wires, infusion pumps, surgical and/or aneurysm clips, shrapnel, metal prostheses, potentially magnetic implants, metal objects in the eye, etc..
  • History of substance abuse or known medical, or psychological, or social conditions, such as alcohol or drug abuse.
  • Allergic, hypersensitive or intolerant to study oncolytic viruses (including any excipients).
  • Vaccination within 30 days prior to administration.
  • Patients who have received gene transfer therapy or treated with any type of oncolytic virus.
  • History of encephalitis, or multiple sclerosis, or other central nervous system (CNS) infections, or primary CNS disease.
  • Male or female patients who refused contraception during the study period and for 6 months after dosing.
  • In the investigator's judgment, there is a serious concomitant disease that endangers the patient's safety or interferes with the patient's ability to complete the study.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
N/A
Model
Single group
Masking
Open label
Primary purpose
Treatment

Study locations

China · 1 center
  • Mianyang Central Hospital — Mianyang

Identifiers

NCT: NCT07145047 · S20230381-02

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗