Synovial Fluid Withdrawal or PRP Injection For Acute ACL Tears and Cytokines
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Synovial Fluid withdrawal at the preoperative clinic visit, Platelet-Rich Plasma (PRP) preparation and injection, Synovial fluid withdrawal at the time of surgery, 3mL synovial fluid withdrawn at the preoperative visit.
- Who it may be relevant to
- Registry conditions: Posttraumatic Osteoarthritis, Anterior Cruciate Ligament (ACL) Rupture. Basic parameters: 18 years — 50 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Does Arthrocentesis and PRP For Acute ACL Tears With Hemarthrosis Decrease Inflammatory Cytokines At Time Of Surgery: A Prospective Randomized Control Trial (RCT)
Overview
The purpose of this study is to determine what effects the withdrawal of excess knee joint fluid or the injection of a factor from the blood has on swelling after a sudden anterior cruciate ligament (ACL) rupture of the knee.
Detailed description
The body responds to different stresses by releasing factors in the blood and fluids in response to stressors like injury, surgery or certain treatments. Some of these factors help heal and some make the injury and body swell (inflammation). In this study we want to see if the intervention of withdrawing fluid the knee or the addition of an enriched healing factor called platelet rich plasma (PRP) injected in the knee influences the body to produce healing factors in the knee joint fluid.
Interventions
- Procedure Synovial Fluid withdrawal at the preoperative clinic visit
Synovial Fluid withdrawal at the preoperative clinic visit - Procedure Platelet-Rich Plasma (PRP) preparation and injection
Platelet-Rich Plasma (PRP) preparation and injection - Procedure Synovial fluid withdrawal at the time of surgery
Synovial fluid withdrawal at the time of surgery - Procedure 3mL synovial fluid withdrawn at the preoperative visit
3mL synovial fluid withdrawn at the preoperative visit
Primary outcome measures
- Concentration of Collagen Type II Cytokine [Time frame: Enrollment up to surgery]
Eligibility criteria
Inclusion criteria
- Age 18 - 50
- English-speaking
- Clinical evidence of ACL rupture with swelling
- Participant must be undergoing ACL reconstruction surgery
Exclusion criteria
- Age <18 or >50
- Presentation >3 weeks after initial injury
- Previous traumatic ipsilateral (same side) knee injury consistent with chronic ACL tear or prior ACL surgery
- > Kellgren-Lawrence grade 2 changes on preoperative x-ray
- History of hemophilia or inflammatory arthropathy (e.g., rheumatoid arthritis)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Other
Study locations
United States · 1 center
- Rush University Medical Center — Chicago
Identifiers
NCT: NCT07142369 · 24120505