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Recruiting NCT07124312

Placental Characteristics Within Monochorionic Twin Pregnancies

— Observational Placenta Monochorionic Twins Anatomy

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
This is an observational study: the protocol does not assign a study treatment.
Who it may be relevant to
Registry conditions: Placenta, Monochorionic Twins, Anatomy. Basic parameters: No limits · Female.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United Kingdom
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Placental Characteristics Within Monochorionic Twin Pregnancies: a Prospective Cohort Study.

Overview

This prospective study aims to collate a comprehensive database of all main monochorionic twin groups to enable comparisons to be made within each twin group and additionally between each group with regards to several placental characteristics, whilst understanding their impact on several fetal outcomes. This study aims to provide new insights in to how the placental architecture influences pregnancy care within the UK pregnancy cohort. Results of this study may impact how clinicians conduct antenatal surveillance for these anatomical placental factors. Patients of both uncomplicated and complication monochorionic twin groups will be consented at a single site and recruited during the antenatal period. Following delivery the placenta will then be analysed macroscopically and assessed for several anatomical features. This will be compared with the antenatal complications and perinatal outcomes for the respective twin.

Primary outcome measures

  • What is the impact of intertwin vascular anastomoses on fetal complications and perinatal outcome [Time frame: Throughout the study period (approximately 2 years)]
  • What is the impact of abnormal cord insertion on fetal complications and perinatal perinatal outcome [Time frame: Throughout the study period (approximately 2 years]
  • What is the impact of twin placental sharing on fetal complications and perinatal outcome [Time frame: Throughout the study period (approximately 2 years)]
Secondary outcome measures (8)
  • The influence of abnormal cord insertion in monochorionic twins complicated by twin-twin transfusion syndrome [Time frame: Throughout the study period (approximately 2 years)]
  • The influence of residual vascular anastomoses monochorionic twins complicated by twin-twin transfusion syndrome [Time frame: Throughout the study period (approximately 2 years)]
  • The influence of abnormal cord insertion on residual anastomoses development in monochorionic twins complicated by twin-twin transfusion syndrome undergoing laser ablation [Time frame: Throughout the study period (approximately 2 years)]
  • Examine the association between Quintero staging during laser ablation for monochorionic twins complicated by twin-twin transfusion syndrome on residual anastomoses development [Time frame: Throughout the study period (approximately 2 years)]
  • Examine the relationship between placenta position during laser ablation for monochorionic twins complicated by twin-twin transfusion syndrome and the rate of residual anastomoses development. [Time frame: Throughout the study period (approximately 2 years)]
  • The influence of intertwin cord distance on fetal complications [Time frame: Throughout the study period (approximately 2 years)]
  • Determine the frequency of abnormal cord insertion in monochorionic twin groups [Time frame: Throughout the study period (approximately 2 years)]
  • Determine the frequency of intertwin anastomoses in monochorionic twin groups [Time frame: Throughout the study period (approximately 2 years)]

Eligibility criteria

Inclusion criteria

  • All consecutive placentas of monochorionic twin pregnancies whereby the placenta is transferred to the pathology department for analysis.

Exclusion criteria

  • Singleton, dichorionic and higher order pregnancies (e.g. triplet).
  • Fetus with known major congenital anomalies or aneuploidy

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model
Cohort

Study locations

United Kingdom · 1 center
  • Birmingham Women's and Children's NHS Foundation Trust — Birmingham

Identifiers

NCT: NCT07124312 · 24/BW/MAT/NO/852

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗