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Идёт набор NCT07124312

Placental Characteristics Within Monochorionic Twin Pregnancies

— Наблюдательное Placenta Monochorionic Twins Anatomy

Ориентир для пациента и семьи

Простыми словами

Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.

Что изучают
Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
Кому может быть актуально
Состояния в реестре: Placenta, Monochorionic Twins, Anatomy. Базовые параметры: Без ограничений · Женщины.
Что важно проверить
Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
Где проводится
Великобритания
Следующий шаг
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Официальное название

Placental Characteristics Within Monochorionic Twin Pregnancies: a Prospective Cohort Study.

Обзор

This prospective study aims to collate a comprehensive database of all main monochorionic twin groups to enable comparisons to be made within each twin group and additionally between each group with regards to several placental characteristics, whilst understanding their impact on several fetal outcomes. This study aims to provide new insights in to how the placental architecture influences pregnancy care within the UK pregnancy cohort. Results of this study may impact how clinicians conduct antenatal surveillance for these anatomical placental factors. Patients of both uncomplicated and complication monochorionic twin groups will be consented at a single site and recruited during the antenatal period. Following delivery the placenta will then be analysed macroscopically and assessed for several anatomical features. This will be compared with the antenatal complications and perinatal outcomes for the respective twin.

Первичные конечные точки

  • What is the impact of intertwin vascular anastomoses on fetal complications and perinatal outcome [Срок оценки: Throughout the study period (approximately 2 years)]
  • What is the impact of abnormal cord insertion on fetal complications and perinatal perinatal outcome [Срок оценки: Throughout the study period (approximately 2 years]
  • What is the impact of twin placental sharing on fetal complications and perinatal outcome [Срок оценки: Throughout the study period (approximately 2 years)]
Вторичные конечные точки (8)
  • The influence of abnormal cord insertion in monochorionic twins complicated by twin-twin transfusion syndrome [Срок оценки: Throughout the study period (approximately 2 years)]
  • The influence of residual vascular anastomoses monochorionic twins complicated by twin-twin transfusion syndrome [Срок оценки: Throughout the study period (approximately 2 years)]
  • The influence of abnormal cord insertion on residual anastomoses development in monochorionic twins complicated by twin-twin transfusion syndrome undergoing laser ablation [Срок оценки: Throughout the study period (approximately 2 years)]
  • Examine the association between Quintero staging during laser ablation for monochorionic twins complicated by twin-twin transfusion syndrome on residual anastomoses development [Срок оценки: Throughout the study period (approximately 2 years)]
  • Examine the relationship between placenta position during laser ablation for monochorionic twins complicated by twin-twin transfusion syndrome and the rate of residual anastomoses development. [Срок оценки: Throughout the study period (approximately 2 years)]
  • The influence of intertwin cord distance on fetal complications [Срок оценки: Throughout the study period (approximately 2 years)]
  • Determine the frequency of abnormal cord insertion in monochorionic twin groups [Срок оценки: Throughout the study period (approximately 2 years)]
  • Determine the frequency of intertwin anastomoses in monochorionic twin groups [Срок оценки: Throughout the study period (approximately 2 years)]

Критерии участия

Критерии включения

  • All consecutive placentas of monochorionic twin pregnancies whereby the placenta is transferred to the pathology department for analysis.

Критерии исключения

  • Singleton, dichorionic and higher order pregnancies (e.g. triplet).
  • Fetus with known major congenital anomalies or aneuploidy

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения
Когортное

Центры проведения

Великобритания · 1 центр
  • Birmingham Women's and Children's NHS Foundation Trust — Birmingham

Идентификаторы

NCT: NCT07124312 · 24/BW/MAT/NO/852

Первоисточники (государственные реестры)

Открыть это исследование на ClinicalTrials.gov ↗