Frequency and Severity of Respiratory Acidosis During One-lung Ventilation, a Retrospective Pilot Study to Compare Clinician Settings and Those Proposed by the VentilO Application
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: one lung ventilation.
- Who it may be relevant to
- Registry conditions: Thoracic, Surgery, Mechanical Ventilation, Hypercapnia. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Canada
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
One-lung ventilation is a mechanical ventilation method frequently used during several thoracic surgeries. One-lung ventilation requires the use of protective ventilation to limit ventilator-induced injury and reduce postoperative respiratory complications. Protective ventilation during one-lung ventilation is specific since tidal volumes are applied by definition to one lung, and it is recommended to use lower tidal volumes, down to 4 ml/kg of ideal body weight. This approach requires individualized ventilation parameters, which differs from the conventional or two-lung ventilation, and there are no clear recommendations regarding respiratory rate adjustment to ensure adequate gas exchange.
Detailed description
The aim of the study is to:
1. Evaluate whether the initial ventilation settings (tidal volume and respiratory rate) during one-lung ventilation are appropriate to prevent respiratory acidosis. 2. Compare the ventilation settings (tidal volume and respiratory rate) made by clinicians with those proposed by an smartphone application ''VentilO''.
Interventions
- Other one lung ventilation
Arterial blood gases during one lung ventilation
Primary outcome measures
- Respiratory acidosis [Time frame: 20 minutes after initiation of one lung ventilation after lung isolation]
Secondary outcome measures (6)
- Respiratory rate [Time frame: At the beginning of one lung ventilation during the surgery]
- Acid-base disorder [Time frame: At the beginning of one lung ventilation during the surgery]
- Number of participants with hemodynamic shock - hypotension [Time frame: Day 1]
- Hospital length of stay [Time frame: Up to 90 days]
- Mechanical Ventilation duration [Time frame: Up to 90 days]
- Hospital mortality [Time frame: Up to 90 days]
Eligibility criteria
Inclusion criteria
- Adults (≥ 18 years old)
- Patients intubated and undergoing one-lung ventilation during thoracic surgery
- Volume-controlled ventilation mode used intraoperatively
Exclusion criteria
- Arterial blood gas data unavailable during one-lung ventilation
- Missing demographic data (sex, height, actual weight)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Cohort
Study locations
Canada · 1 center
- Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval — Québec
Identifiers
NCT: NCT07099963 · 2026-4405