The Predictive Value of Doppler Based Renal Ultrasound and Urinary Oxygen Tension for Prediction of Acute Kidney Injury After Open Heart Surgery
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An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Renal resistive index, Renal Artery Pulsatility Index, Urinary oxygen tension (PUO2).
- Who it may be relevant to
- Registry conditions: Doppler-Based Renal Ultrasound, Urinary Oxygen Tension, Acute Kidney Injury, Open Heart Surgery. Basic parameters: from 21 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
This study aims to investigate the predictive value of Doppler-based renal ultrasound and urinary oxygen tension in the development of acute kidney injury after cardiac surgery.
Detailed description
Cardiac surgery-associated acute kidney injury (CSA-AKI) is a complication following cardiac surgery occurring in 15-30% of patients. It is associated with increased morbidity and mortality as well as prolonged hospital stay and higher medical costs.
The renal artery pulsatility index (RAPI), which is determined using Doppler measurements, has been reported to detect patients with a high risk of AKI. Additionally, the renal resistance index (RRI), measured by Doppler ultrasound, can accurately predict the occurrence of AKI.
Urinary oxygen partial pressure in the bladder has been shown to decrease in the setting of sepsis, reduced renal blood flow, and decreased cardiac output.
Interventions
- Other Renal resistive index
It will be measured with ultrasound-Doppler using an abdominal curvilinear probe ultrasonography by two independent, trained sonographers (who will not be involved in patient care). After visualizing the kidney in ultrasound mode and checking for renal abnormalities, an arcuate or inter-lobar artery will be localized, and three successive Doppler measurements at different positions in the kidney (high, middle, and low) will be performed. The average value for each kidney will be taken. The rena - Other Renal Artery Pulsatility Index
It will be measured using an abdominal curvilinear probe ultrasonography by two independent, trained sonographers (who will not be involved in patient care). After visualizing the kidney, the interlobular artery will be located using color Doppler mode, and the velocity of the interlobular arteries will be assessed in one or two kidneys. The Renal Artery Pulsatility Index (RAPI) will be calculated as follows: RAPI = \[(peak systolic velocity) - (end diastolic velocity)\] /average velocity - Other Urinary oxygen tension (PUO2)
Urinary oxygen tension (PUO2) will be measured preoperatively (baseline), postoperatively just after intensive care unit admission, 12 hours after surgery, and then once daily for 7 days.
Primary outcome measures
- Number of cases developed acute kidney injury [Time frame: 7 days after the procedure]
Secondary outcome measures (5)
- Length of intensive care unit stay [Time frame: 7 days after the procedure]
- Length of hospital stay [Time frame: 7 days after the procedure]
- Need for renal replacement therapy [Time frame: 7 days after the procedure]
- Number of patients developed chronic kidney disease [Time frame: 7 days after the procedure]
- Mortality rate [Time frame: 7 days after the procedure]
Eligibility criteria
Inclusion criteria
- Age above 21 years.
- Both sexes.
- Undergoing elective on-pump cardiac surgery.
Exclusion criteria
- Patients with chronic kidney disease.
- Patients with any renal pathology or anatomic kidney abnormalities.
- Patients on renal replacement therapy.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Egypt · 1 center
- Tanta University — Tanta
Identifiers
NCT: NCT07037485 · 36265MD279/9/24