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Recruiting NCT06998966

Optimizing Proton Pump Inhibitors (PPI) Prescribing With EHR-Based Decision Support

No phase Interventional Prescribing Patterns, Physician Physician's Practice Patterns Drug Utilization Review

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Algorithmic Defaulting (Indication-Based Default), Active Physician Choice.
Who it may be relevant to
Registry conditions: Prescribing Patterns, Physician, Physician's Practice Patterns, Drug Utilization Review. Basic parameters: from 50 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Quality Improvement Initiative Leveraging Electronic Healthcare Records to Reduce Inappropriate Proton Pump Inhibitors (PPI) Prescribing at UCLA.

Overview

The proposed study is a quality improvement initiative designed to rigorously evaluate new variations of UCLA Health's proton pump inhibitor (PPI) order panels, building on internal quality improvement efforts to optimize prescribing workflows within the Electronic Health Record (EHR). PPIs are notoriously overprescribed, and the study team has identified that the CareConnect default prescription setting of 90 days with three refills (360 pill days) exceed standard guidelines (in most cases, 60 pill days). It is unclear whether this is the most appropriate workflow. Given that deprescribing PPIs carries minimal risk for most patients, this initiative will assess whether modifying defaulted prescription lengths influences prescribing behavior while ensuring physicians retain full decision-making authority. This evaluation of PPI order panel variations is embedded within UCLA's existing EHR system, ensuring that changes are tested pragmatically within routine workflows. The study aims to determine whether small adjustments to the order panel can better align prescribing patterns with clinical best practices while maintaining physician autonomy.

Interventions

  • Behavioral Algorithmic Defaulting (Indication-Based Default)
    PPIs are frequently overprescribed, and the CareConnect default prescription setting of 90 days with three refills (360 pill days) exceed standard guidelines (in most cases, 60 pill days). It is unclear whether this is the most appropriate workflow. Given that deprescribing PPIs carries minimal risk for most patients, this initiative will assess whether modifying defaulted prescription lengths influences prescribing behavior while ensuring physicians retain full decision-making authority.
  • Behavioral Active Physician Choice
    PPIs are frequently overprescribed, and the CareConnect default prescription setting of 90 days with three refills (360 pill days) exceed standard guidelines (in most cases, 60 pill days). It is unclear whether this is the most appropriate workflow. Given that deprescribing PPIs carries minimal risk for most patients, this initiative will assess whether requiring providers to actively select prescription lengths influences prescribing behavior while ensuring physicians retain full decision-makin

Primary outcome measures

  • Inappropriate Pill Days [Time frame: 12 months]
Secondary outcome measures (4)
  • Prescription Discontinuations [Time frame: 12 months]
  • Prescription Refills [Time frame: 12 months]
  • Overall Average Pill Days [Time frame: 12 months]
  • GI Bleeding Hospitalization [Time frame: 12 months]

Eligibility criteria

Inclusion criteria

  • UCLA Health primary care physicians who have a clinical full-time equivalency of at least 25%.

Exclusion criteria

  • Physicians with a clinical full-time equivalency of less than 25%

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Double blind
Primary purpose
Health services research

Study locations

United States · 1 center
  • UCLA Health System — Los Angeles

Identifiers

NCT: NCT06998966 · IRB-25-0231 · 1K76AG064392-01A1

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗