A Prospective Cohort Study on Primary Cutaneous Amyloidosis
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Tofacitinib and Acitretin Capsules., Acitretin Capsules..
- Who it may be relevant to
- Registry conditions: Primary Cutaneous Amyloidosis. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
A Prospective Cohort Study on the Efficacy and Safety Comparison of Tofacitinib Citrate Tablets Combined With Acitretin Capsules Versus Acitretin Capsules Alone in the Treatment of Primary Cutaneous Amyloidosis
Overview
The aim of this clinical trial is to find out whether the combination of tocilizumab tablets and acitretin capsules is more effective than acitretin capsules alone in treating primary cutaneous amyloidosis. It will also investigate the safety of the combination of tocilizumab tablets and acitretin capsules. The main questions it aims to answer are: 1. Does the combination of tocilizumab tablets and acitretin capsules relieve the pruritus symptoms of the participants faster and reduce the pruritus score more than acitretin capsules alone? 2. What medical problems will the participants encounter when taking tocilizumab tablets combined with acitretin capsules? The researchers compared the combination of tocilizumab tablets and acitretin capsules with acitretin capsules alone to see if the combination could better treat primary cutaneous amyloidosis without causing serious adverse reactions. Participants will: 1. Take the combination of tocilizumab tablets and acitretin capsules or acitretin capsules alone every day for 16 weeks. 2. Visit the clinic once every 4 weeks for checkups and tests. 3. Observe participants at 4 weeks, 12 weeks and 24 weeks after discontinuation of medication to determine the recurrence status. 4. Collect the visual analogue scale (VAS) scores for pruritus, symptom severity (SCORAD) scores , rash area and severity, treatment response (EASI) scores, dermatological quality of life index (DLQI), and insomnia severity index (ISI) of participants before and after treatment.
Interventions
- Drug Tofacitinib and Acitretin Capsules.
The same with Arms. - Drug Acitretin Capsules.
The same with Arms.
Primary outcome measures
- Visual analogue scale (VAS) scores for pruritus. [Time frame: Week 0, Week 4, Week 8, Week 12 and Week 16.]
Secondary outcome measures (7)
- SCORAD index. [Time frame: Week 0, Week 4, Week 8, Week 12 and Week 16.]
- EASI Index. [Time frame: Week 0, Week 4, Week 8, Week 12 and Week 16.]
- DLQI. [Time frame: Week 0, Week 4, Week 8, Week 12 and Week 16.]
- ISI. [Time frame: Week 0, Week 4, Week 8, Week 12 and Week 16.]
- The onset time of drug efficacy. [Time frame: Up to 8 weeks.]
- Recurrence rate. [Time frame: Within 24 weeks after the treatment concludes.]
- Incidence rate of adverse events. [Time frame: Week 4, Week 8, Week 16 and Week 20.]
Eligibility criteria
Inclusion criteria
- Age ≥ 18 years old, without infectious diseases such as "hepatitis B" and "tuberculosis" and major underlying diseases (gender not limited);
- "Outpatient Diagnosis" includes "primary cutaneous amyloidosis", "macular amyloidosis" or "lichen amyloidosis";
- Visited the outpatient department for PCA treatment for 4 times or more;
- The medication record shows "Avastin Capsules" and/or "Tofacitinib Citrate";
- The medical record fully records baseline characteristics, medication dosage, efficacy assessment and adverse events.
Exclusion criteria
- Nodular amyloidosis or combined with other types of amyloidosis (such as systemic amyloidosis);
- During the study period, other immunosuppressants (such as glucocorticoids, methotrexate) or biologics were used;
- Incomplete medical records such as demographic data, laboratory parameters, prescription administration and patient prognosis, as well as irregular treatment, etc.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Quadruple blind
- Primary purpose
- Treatment
Study locations
China · 1 center
- Department of Dermatology, Southwest Hospital, Third Military Medical University (Army Med — Chongqing
Identifiers
NCT: NCT06998875 · KY2025060