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Not yet recruiting NCT06921408

Retrospective Identification of Scintigraphic Cardiac Amyloidosis (RISCA)

— Observational Cardiac Amyloidosis Transthyretin Amyloidosis

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
This is an observational study: the protocol does not assign a study treatment.
Who it may be relevant to
Registry conditions: Cardiac Amyloidosis, Transthyretin Amyloidosis. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Center list to be confirmed — check the primary protocol.
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Retrospective Identification of Scintigraphic Cardiac Amyloidosis Using Deep Learning-based Model

Overview

This study aims to determine the positive predictive value of incidental cardiac uptake on bone scintigraphy for diagnosing transthyretin cardiac amyloidosis, in patients who underwent scintigraphy for reasons other than suspected amyloidosis. The study is an observational, descriptive, multicenter, national study using retrospective data from routine care. Patients with incidental cardiac uptake will be recalled for further diagnostic assessment.

Primary outcome measures

  • Cardiac amyloidosis diagnosis [Time frame: After the reassessment evaluation (one-day evaluation)]

Eligibility criteria

Inclusion criteria

  • Adults (≥ 18 years)
  • Patients who underwent bone scintigraphy with 99mTc-HMDP/DPD/PYP for any indication
  • Incidental cardiac uptake (Perugini grade ≥2) confirmed by a nuclear medicine specialist

Exclusion criteria

  • Patients under legal protection
  • Patients refusing the reuse of their data after individual information

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

Center list to be confirmed — check the primary protocol.

Identifiers

NCT: NCT06921408 · 2024_0111 · ID RCB Number

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗