HLA Antibodies in Systemic Lupus Erythematosus
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: HLA Antibodies, Systemic Lupus Erythematosus. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Patients suffering from autoimmune diseases show false-positive results when anti-HLA antibodies are identified. This false positivity makes it difficult to obtain an organ transplant based on immunological compatibility (absence of anti-HLA antibodies directed against graft antigens). The objectives of this project are to study the prevalence of these false positivities in a population of lupus patients, and to evaluate biological tests that can negate these false positivities.
Primary outcome measures
- prevalence of unexplained antibody positivity [Time frame: 6 months]
Eligibility criteria
Inclusion criteria
- Patients Adults
- Followed in the internal medicine department of Amiens University Hospital - With systemic lupus erythematosus
- Without HLA immunization risk factors (no history of pregnancy, transfusions or transplants)
- With sera stored in the biobank
Exclusion criteria
- minor Patients
- Opposing the re-use of their personal data for research purposes
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-only
Study locations
France · 1 center
- CHRU Amiens — Amiens
Identifiers
NCT: NCT06921239 · PI2025_843_0043