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Recruiting NCT06910449

Hemithoracic Arc Radiotherapy Post Pleural Decortication

No phase Interventional Malignant Pleural Mesothelioma

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: hemithoracic Volumetric Arc Radiotherapy post Pleural decortication.
Who it may be relevant to
Registry conditions: Malignant Pleural Mesothelioma. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Egypt
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Hemithoracic Volumetric Modulated Arc Radiotherapy as Part of Lung-Sparing Multimodality Therapy in Patients With Malignant Pleural Mesothelioma Phase II Trial

Overview

Malignant Pleural Mesothelioma is an aggressive and refractory disease , the most aggressive treatment plan offered to these patients include trimodalitiy approach with chemotherapy as the mainstay of treatment . the rationale of post operative Radiotherapy is to sterilize the post operative volume to reduce local failure meanwhile minimizing toxicities in this trial we are going to assess the safety and efficacy of Radiotherapy in Mesothelioma patients poat Pleural decortication

Detailed description

This study will include malignant Pleural Mesothelioma patients treated by trimodalitiy approach starting with neoadjuvant chemotherapy followed by surgery in the form of Pleural decortication then all patients will receive post operative hemithoracic radiation

Interventions

  • Radiation hemithoracic Volumetric Arc Radiotherapy post Pleural decortication
    post operative delivery of hemithoracic Volumetric Arc Radiotherapy

Primary outcome measures

  • Acute Radiation Toxicity [Time frame: weekly assessment during radiation course and monthly follow up for the first 6 months]
  • late radiation toxicity [Time frame: Bi-monthly fashion of minimum 6 months post radiation course]

Eligibility criteria

Inclusion criteria

  • Evidence of metastatic disease.
  • Underwent Pleural decortication.
  • Able to provide informed consent.

Exclusion criteria

  • Poor pulmonary function tests.
  • Recurrent or palliative cases.
  • Inability to attend full course of Radiotherapy or follow up visits.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
N/A
Model
Single group
Masking
Open label
Primary purpose
Other

Study locations

Egypt · 1 center
  • national Cancer Institute Cairo university — Cairo

Identifiers

NCT: NCT06910449 · RO2405-291-047-193

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗