Cardioprotective Effects of Melatonin in Patients With Cardiomyopathy

Cardiomyopathy is a progressive and debilitating condition characterized by structural and functional abnormalities of the myocardium, often leading to impaired cardiac function, systemic congestion, and organ dysfunction. It affects millions of individuals worldwide, contributing significantly to morbidity and mortality despite advances in medical management. The pathophysiology of cardiomyopathy is complex and multifactorial, involving neurohormonal activation, oxidative stress, inflammation, and adverse cardiac remodeling. Standard treatments, such as angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, and diuretics, have been shown to improve symptoms and slow disease progression; however, the prognosis remains poor for many patients, emphasizing the urgent need for novel therapeutic strategies.

Melatonin, a neurohormone primarily secreted by the pineal gland, has attracted considerable interest due to its diverse biological properties. Beyond its role in regulating circadian rhythms, melatonin exhibits potent antioxidant and anti-inflammatory effects. It scavenges free radicals, reduces lipid peroxidation, and modulates inflammatory pathways, thereby protecting mitochondrial function and cellular integrity. Experimental studies have demonstrated melatonin's ability to mitigate myocardial injury and improve cardiac function in animal models of cardiomyopathy. Preliminary clinical studies also suggest that melatonin supplementation may improve endothelial function, reduce sympathetic overactivity, and enhance overall cardiovascular health .

Mitochondrial dysfunction is a hallmark of cardiomyopathy. Melatonin has been shown to preserve mitochondrial function by maintaining mitochondrial membrane potential, preventing the opening of the mitochondrial permeability transition pore, and promoting mitophagy-the selective removal of damaged mitochondria. These actions help sustain ATP production and reduce cardiomyocyte apoptosis .

Melatonin's antioxidant capacity extends beyond direct scavenging; melatonin also upregulates the expression of antioxidant enzymes like superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase, while simultaneously inhibiting pro-oxidant enzymes. This dual mechanism makes it particularly effective in mitigating oxidative stress, a key contributor to the pathogenesis of numerous diseases, including cardiovascular disorders, neurodegenerative diseases like Alzheimer's and Parkinson's, diabetes, and cancer. In cardiovascular diseases, melatonin reduces lipid peroxidation and preserves mitochondrial function, protecting against ischemia-reperfusion injury. In neurodegenerative conditions, it minimizes neuronal oxidative damage and supports synaptic integrity. Furthermore, in diabetes, melatonin helps maintain pancreatic β-cell function by countering oxidative stress and inflammation. These multifaceted antioxidant properties make melatonin a promising therapeutic agent in oxidative stress-driven pathologies Given its safety profile and multifaceted mechanisms of action, melatonin holds promise as an adjunctive therapy in managing cardiomyopathy. Its ability to target oxidative stress, inflammation, and mitochondrial dysfunction addresses key pathological processes underlying the disease

In summary, melatonin exhibits several properties that may be beneficial in the context of cardiomyopathy. Ongoing research is essential to fully elucidate its therapeutic potential and to determine optimal dosing strategies for affected patients.

• composite clinical endpoint score [Time frame: baseline , up to 3 month]
• Biochemical Markers [Time frame: baseline , up to 3 month]