Phase 1 Trial of BTM-3566 in Relapsed/Refractory Mature B Cell Lymphomas
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: BTM-3566.
- Who it may be relevant to
- Registry conditions: Lymphoma, B-Cell. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Phase 1A/1B Trial of BTM-3566 in Relapsed/Refractory Mature B Cell Lymphomas
Overview
The goal of this clinical trial is to learn if BMT-3566 can safety be given to adult patients with relapsed or refractory mature b cell lymphomas. It will also learn how well BTM-3566 works to treat relapsed or refractory mature b cell lymphomas. The main questions it aims to answer are: What are the side effects of BTM-3566 at different doses? What are the levels of BTM-3566 in the blood at different timepoints around dosing? What is the clinical benefit of BTM-3566 in treating cancer (i.e. how well does it slow or stop disease progression)? Participants will: Take BTM-3566 in 14-day periods with 7 days of dosing followed by 7 days of no dosing Visit the clinic regularly for checkups and tests Keep a diary of their dosing and weight
Detailed description
This is an open label, phase 1 dose escalation trial of BTM-3566 in relapsed/refractory mature b cell lymphomas. Dose escalation will utilize traditional 3+3 methodology to determine the maximum tolerated dose of BTM-3566. Treatment will be given as two-week cycles, with BTM-3566 taken daily during the first week of the cycle, and the second week 'off therapy'. DLT window will be the first two cycles of therapy (days 1 to 28). All enrolled patients will undergo a baseline FDG-PET/CT scan within 3 weeks prior to starting therapy. FDG-PET/CT will be repeated at the start of Cycles 3 and 5 or more frequently as clinically indicated. Beginning at Cycle 5, imaging will be repeated every 3 months (or as clinically indicated) for up to 12 months, and every 6 months thereafter, until disease progression or start of subsequent anti-cancer therapy.
Interventions
- Drug BTM-3566
Oral Solution
Primary outcome measures
- Adverse Event and dose-limiting toxicity event rates [Time frame: 24 months]
Eligibility criteria
Inclusion criteria
- must be age ≥18 years
- must have a diagnosis of relapsed or refractory mature B cell lymphoma
- must have measurable disease per response evaluation criteria in lymphoma (Lugano classification)
- must have an Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-2
- must have a predicted life expectancy of ≥3 months
- must agree to use adequate birth control throughout their participation and for 90 days following the last dose of BTM-3566
Exclusion criteria
- has primary CNS lymphoma
- has ongoing toxicities from prior anti-cancer treatment > Grade 1
- has symptomatic or uncontrolled neurologic disease (brain metastases, leptomeningeal disease, or spinal cord compression) not definitively treated with surgery or radiation
- has received any anti-cancer therapy (including radiation of curative intent) <28 days prior to administration of BTM-3566
- has current second malignancy at other sites (exceptions: non-melanomatous skin cancer, adequately treated in situ carcinoma, or indolent prostate cancer under observation).
- is pregnant or breastfeeding
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
United States · 2 centers
- Levine Cancer Institute, Atrium Health — Charlotte
- MD Anderson Cancer Center — Houston
Identifiers
NCT: NCT06792734 · BTM-3566-001