Evaluation of the Reproducibility of the Automated Measurement of the Extent of ILD on Chest CT
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In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Chest CT.
- Who it may be relevant to
- Registry conditions: Interstitial Lung Disease. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Evaluation of the Reproducibility of the Automated Measurement of the Extent of Interstitial Lung Disease on Chest CT
Overview
In interstitial lung disease (ILD), the extent of ILD on chest computed tomography (CT) is recognized as an important prognostic factor. Automated tools are now available to quantify ILD, but there is a lack of data on the reproducibility of this measurement and therefore its accuracy. Therefore, the purpose of this study is to evaluate the variability of automated ILD quantification on chest CT. Reproducibility will be assessed by repeating chest CT scans and using different tools to measure the extent of disease.
Detailed description
In interstitial lung disease (ILD), the extent of ILD on chest computed tomography (CT) is recognized as an important prognostic factor. In recent years, several tools based on texture analysis or deep learning methods have been developed to provide rapid and accurate automated quantification of ILD extent.
An advantage of automated scoring methods is that they theoretically offer perfect repeatability of measurement. However, this is only true if the measurement is repeated on the same images. Several parameters can alter the appearance of the lungs on scanner images, such as the degree of inspiration or the reconstruction kernel used to reconstruct the images. There is a lack of data on the reproducibility of the whole process of automated ILD quantification and therefore its accuracy.
Therefore, the purpose of this study is to evaluate the variability of automated ILD quantification on chest CT.
Reproducibility will be assessed by repeating chest CT scans and using different tools to measure the extent of disease in patients with ILD from 2 institutions. Chest CT will be repeated the same day. This will allow assessment of the variability of automated measurement of ILD extent between 2 CT scans performed on the same day and when using different software. It will also allow to assess the variability of lung volume between the 2 CT scans and the effect of disease (idiopathic pulmonary fibrosis or connective tissue disease-related ILD) on the reproducibility of ILD quantification.
Interventions
- Diagnostic test Chest CT
Repeated chest CT for automated ILD quantification
Primary outcome measures
- Automated Interstitial Lung Disease (ILD) quantification [Time frame: Day of inclusion]
Secondary outcome measures (3)
- Automated Interstitial Lung Disease (ILD) quantification [Time frame: Day of inclusion]
- Lung volume [Time frame: Day of inclusion]
- Automated Interstitial Lung Disease (ILD) quantification [Time frame: Day of inclusion]
Eligibility criteria
Inclusion criteria
- Age ≥ 18 years
- Known interstitial lung disease as part of idiopathic pulmonary fibrosis or connective tissue disease
- Followed in one of the participating hospitals
- Requiring a chest CT as part of a scheduled assessment
- Affiliated to a French national social security
- Informed consent
Exclusion criteria
- Acute exacerbation of ILD
- Pregnancy
- Inability to hold an apnea for 10 seconds
- Patients in the exclusion period after a previous research
- Need for additional procubitus or expiratory images
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Other
Study locations
France · 6 centers
- APHP - Bichat hospital - Radiology — Paris
- APHP - Bichat hospital - Rheumatology — Paris
- APHP - Cochin Hospital - Internal medicine — Paris
- APHP - Cochin Hospital - Pneumology — Paris
- APHP - Cochin Hospital - Radiology — Paris
- APHP - Bichat Hospital - Pneumology — Paris
Identifiers
NCT: NCT06743022 · APHP240783 · 2024-A01384-43