Effects of Upper Extremity-Focused Neuromuscular Training in People With Multiple Sclerosis
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Neuromuscular Exercise Training, Conventional Exercise Training.
- Who it may be relevant to
- Registry conditions: Multiple Sclerosis. Basic parameters: 18 years — 64 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Effects of Upper Extremity-Focused Neuromuscular Exercise Training on Physical and Cognitive Functions in People With Multiple Sclerosis (NExTUp)
Overview
The effectiveness of upper extremity focused neuromuscular exercise training in early stage people with MS will be investigated. People with MS enrolled in the study will be randomly assigned to three groups: Neuromuscular Exercise Group (NEG), Conventional Exercise Group (CEG), and Control Group (CG). All three groups will be assessed with primary and secondary outcome measures at baseline, week 8, and week 12. NEG, CEG, and CG will be initially assessed for upper extremity function, cognitive function, lower extremity function, grip strength, proximal muscle strength, sensation, coordination, fatigue, postural sway, and core muscle strength and endurance. Then, NEG will receive clinically supervised upper extremity focused neuromuscular exercise training with a minimum of 60 minutes of session time, 2 days a week for 8 weeks. This exercise training includes steps for postural control, weight transfer, proximal and distal muscle strengthening, proprioception, coordination and reaction speed. Similarly, CEG will receive clinically supervised traditional upper extremity exercise training, twice a week for 8 weeks, with a minimum of 60 minutes of session time. This exercise training includes strengthening with the band and manuel dexterity exercises. In both groups, stretching and mobility exercises will be added to the warm-up and cool-down exercises before and after the program. During this process, CG will be on the waiting list. At the end of 8 weeks, all three groups will be re-evaluated. After the exercise training, follow-up will be done and evaluations will be repeated in the 12th week. This study will provide evidence on the effects of upper extremity-focused neuromuscular exercise training on physical and cognitive functions in early-stage people with MS compared to traditional treatment approaches.
Interventions
- Other Neuromuscular Exercise Training
This group will receive neuromuscular exercise training with 60-75 minute sessions per day, 2 days a week, for 8 weeks. Warm-up Program - 5 minutes Postural Control-Weight Transfer - 10-15 minutes Strength Training - 30-35 minutes Proprioception - Coordination - Reaction Speed 10-15 minutes Cool-down Program - 5 minutes - Other Conventional Exercise Training
This group will be given traditional strength exercise training consisting of 60-75 minute sessions per day, 2 days per week for 8 weeks. Warm-up Program - 5 minutes Strength Training - 30-35 minutes Manuel Dexterity - 15-20 minutes Cool-down Program - 5 minutes
Primary outcome measures
- Nine Hole Peg Test [Time frame: At the beginning, at the end of 8 weeks and 12 weeks]
- Minnesota Manual Dexterity Test [Time frame: At the beginning, at the end of 8 weeks and 12 weeks]
- Manual Ability Measure-36 [Time frame: At the beginning, at the end of 8 weeks and 12 weeks]
- Timed 25-Foot Walk [Time frame: At the beginning, at the end of 8 weeks and 12 weeks]
- Symbol Digit Modalities Test [Time frame: At the beginning, at the end of 8 weeks and 12 weeks]
- Hand Dynamometer [Time frame: At the beginning, at the end of 8 weeks and 12 weeks]
Secondary outcome measures (7)
- Hand Held Dynamometer [Time frame: At the beginning, at the end of 8 weeks and 12 weeks]
- Biodex Balance System [Time frame: At the beginning, at the end of 8 weeks and 12 weeks]
- Laser-pointer Assisted Angle Reproduction Test [Time frame: At the beginning, at the end of 8 weeks and 12 weeks]
- Finger Tapping Test [Time frame: At the beginning, at the end of 8 weeks and 12 weeks]
- Fatigue Severity Scale [Time frame: At the beginning, at the end of 8 weeks and 12 weeks]
- Plank [Time frame: At the beginning, at the end of 8 weeks and 12 weeks]
- Curl-up [Time frame: At the beginning, at the end of 8 weeks and 12 weeks]
Eligibility criteria
Inclusion criteria
- Definite MS according to McDonald criteria,
- 18-64 years
- RRMS,
- EDSS < 4,
- Minimal or moderate upper extremity involvement
Exclusion criteria
- Having an attack in the last three months,
- Mini Mental Test <24 or visual deficit,
- Other medical conditions accompanying MS (cardiac, orthopedic or rheumatic, etc.),
- Being pregnant or breastfeeding,
- Doing regular exercise - receiving physiotherapy,
- Having spasticity of 2 or more in the upper extremity
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Treatment
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT06712342 · 2024/125