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Recruiting NCT06696638

Physiological Effects of Lung Impedance Tomography-Guided and Plat Pressure-Guided Phigh During APRV in Patients With ARDS

No phase Interventional ARDS: Acute Respiratory Distress Syndrome

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: EIT-guided Phigh settings during APRV.
Who it may be relevant to
Registry conditions: ARDS: Acute Respiratory Distress Syndrome. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
China
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Physiological Effects of Lung Impedance Tomography-guided and Plat Pressure-guided Phigh During Airway Pressure Release Ventilation in Patients With Acute Respiratory Distress Syndrome

Overview

This study aims to investigate the effects of EIT-guided and Pplat-guided Phigh settings on regional ventilation and perfusion in ARDS patients during APRV, while also examining the impact of different Phigh settings on gas exchange, respiratory mechanics, and hemodynamics.

Interventions

  • Device EIT-guided Phigh settings during APRV
    The Phigh level selected for the patients in the Intervention group was the intercept point of cumulated collapse and overdistension percentage curves, providing the best compromise between collapsed and overdistended lung.

Primary outcome measures

  • The effects of Phigh guided by different methods on regional lung ventilation assessed by EIT [Time frame: 1 Hour Post-Intervention]
Secondary outcome measures (5)
  • Global inhomogeneity assessed by electrical impedance tomography [Time frame: 1 Hour Post-Intervention]
  • Center of ventilation assessed by electrical impedance tomography [Time frame: 1 Hour Post-Intervention]
  • ventilation/perfusion matching assessed by EIT [Time frame: 1 Hour Post-Intervention]
  • Respiratory system compliance [Time frame: 1 Hour Post-Intervention]
  • mean arterial pressure [Time frame: 1 Hour Post-Intervention]

Eligibility criteria

Inclusion criteria

  • Diagnosed with ARDS according to the 2023 global new definition of ARDS.
  • Age ≥ 18 years.

Exclusion criteria

  • Severe chronic obstructive pulmonary disease, severe asthma, pulmonary bullae, pneumothorax, subcutaneous emphysema, mediastinal emphysema, etc. · Contraindications for EIT, such as chest wound dressing, pacemaker implantation, defibrillator use, etc.
  • Pulmonary interstitial disease.
  • Uncorrected shock of various types.
  • Intracranial hypertension.
  • Pregnant and postpartum women.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Crossover
Masking
Single blind
Primary purpose
Treatment

Study locations

China · 1 center
  • Wuhan Union hospital — Wuhan

Identifiers

NCT: NCT06696638 · APRVPhigh2024

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗