Recruiting NCT06679101

A Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM)

Phase III Interventional Multiple Myeloma Newly Diagnosed Multiple Myeloma

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied: The protocol lists: Belantamab mafodotin, Lenalidomide, Dexamethasone, Daratumumab.
Who it may be relevant to: Registry conditions: Multiple Myeloma, Newly Diagnosed Multiple Myeloma. Basic parameters: from 18 years · All.
What needs checking: Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place: United States, Argentina, Australia, Belgium, Brazil +19
Next step: Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

A Phase 3, Randomized, Open-label Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM)

Overview

The purpose of this Phase 3 study is to evaluate if BRd prolongs progression free survival (PFS) and/or improves minimal residual disease (MRD) negative status compared with DRd in participants with TI-NDMM.

Interventions

Drug Belantamab mafodotin
Belantamab mafodotin will be administered.
Drug Lenalidomide
Lenalidomide will be administered.
Drug Dexamethasone
Dexamethasone will be administered.
Drug Daratumumab
Daratumumab will be administered.

Primary outcome measures

PFS [Time frame: Up to approximately 7 years]
Number of Participants Achieving MRD Negative Status [Time frame: Up to approximately 7 years]

Secondary outcome measures (12)

Overall Survival (OS) [Time frame: Up to approximately 7 years]
PFS2 [Time frame: Up to approximately 7 years]
Number of Participants Achieving CR or Better (CR+) [Time frame: Up to approximately 7 years]
Number of Participants Achieving Very Good Partial Response (VGPR) or Better [Time frame: Up to approximately 7 years]
Number of Participants Achieving Sustained MRD Negative Status [Time frame: Up to approximately 7 years]
Duration of Response (DoR) [Time frame: Up to approximately 7 years]
Time to Second Next Line Therapy (TTST) [Time frame: Up to approximately 7 years]
Number of Participants With Adverse Events (AEs) [Time frame: Up to approximately 7 years]
Number of Participants With Ocular Findings on Ophthalmic Exam [Time frame: Up to approximately 7 years]
Maximum Post-baseline Patient-Reported Outcomes Version of the Common Term Criteria for Adverse Events (PRO-CTCAE) Score [Time frame: Up to approximately 7 years]
Change From Baseline in European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-C30 [Time frame: Up to approximately 7 years]
Change From Baseline in EORTC QLQ-MY20 [Time frame: Up to approximately 7 years]

Eligibility criteria

Inclusion criteria

Is at least 18 or the legal age of consent in the jurisdiction in which the study is taking place, at the time of signing the informed consent.
Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the informed consent form and in the protocol.
NDMM with a requirement for treatment as documented per IMWG criteria.
Must have at least 1 aspect of measurable disease, as assessed by the central laboratory, defined as 1 of the following:

Urine M-protein excretion ≥200 mg/24 hours (≥0.2 g/24 hours) And/or
Serum M-protein concentration ≥0.5 g/dL (≥5.0 g/L) And/or
Serum free light-chain (FLC) assay: involved FLC level ≥10 mg/dL (≥100 mg/L) and an abnormal serum FLC ratio (<0.26 or >1.65).
Newly diagnosed and not considered candidate for high-dose chemotherapy with autologous stem cell transplant (ASCT) due to any of the following:

Exclusion from treatment with ASCT due to country- or site-specific age restriction.
Presence of comorbid condition(s) likely to have a negative impact on tolerability of high-dose chemotherapy with ASCT.
Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2.
Adequate organ system function as defined by the laboratory assessments.
Male participants:

Contraceptive use by men should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.
Male participants are eligible to participate if they agree to the following during the Treatment Period and for at least 6 months after the last dose of study intervention to allow for clearance of any altered sperm:
Refrain from donating fresh unwashed semen

PLUS either:

Be abstinent from heterosexual intercourse as their preferred and usual lifestyle (abstinent on a long term and persistent basis) and agree to remain abstinent.

Must agree to use contraception/barrier as detailed below
Agree to use a male condom, even if they have undergone a successful vasectomy, and female partner to use an additional highly effective contraceptive method with a failure rate of <1% per year when having sexual intercourse with a woman of childbearing potential (WOCBP) who is not currently pregnant. Male participants should also use a condom when having sexual intercourse with pregnant females.
Female participants

Contraceptive use by women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.
A female participant is eligible to participate if she is not pregnant or breastfeeding, and at least 1 of the following conditions applies:
Is not a WOCBP OR
Is a WOCBP and using a contraceptive method that is highly effective (with a failure rate of <1% per year), preferably with low user dependency during the Treatment Period and for 4 months after the last dose of study intervention and agrees not to donate eggs (ova, oocytes) for the purpose of reproduction during this period. The investigator should evaluate the effectiveness of the contraceptive method in relationship to the first dose of study intervention.
A WOCBP must have 2 negative highly sensitive serum pregnancy tests before starting treatment, the first may be performed within 14 days from C1D1, the second within 24 hours before the first dose of study intervention.
Should pregnancy occur in a female on treatment or the female partner of a male on treatment, treatment must be stopped, and it is advised to seek advice from a physician specialized or experienced in teratology.

Exclusion criteria

Diagnosis of systemic amyloid light chain amyloidosis, Waldenstrom's disease, POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma proliferative disorder, skin changes) or Primary Plasma Cell Leukemia (defined as circulating plasma cells >5%).
Prior systemic therapy for multiple myeloma, or smoldering multiple myeloma.
Signs of meningeal or central nervous system involvement with multiple myeloma.
Major surgery within 2 weeks prior to the first dose of study drugs or has not recovered fully from surgery. Kyphoplasty is not considered major surgery.
Any serious and/or unstable pre-existing medical, psychiatric disorder or other conditions (including lab abnormalities) that could interfere with participant's safety, obtaining informed consent, or compliance with study procedures.
Current active liver or biliary disease (except for Gilbert's syndrome or asymptomatic gallstones, or otherwise stable chronic liver disease as per the investigator's assessment).
Participants with previous or concurrent malignancies other than multiple myeloma are excluded. Exceptions are any other malignancy that has been considered medically stable for at least 2 years, after discussion with the GSK Medical Monitor. The participant must not be receiving active therapy, other than hormonal therapy for this disease.
Evidence of cardiovascular risk including any of the following:

Evidence of current clinically significant untreated arrhythmias, including clinically significant electrocardiogram abnormalities including second-degree (Mobitz Type II) or third-degree atrioventricular block.
Recent history (within 3 months of screening) of myocardial infarction, acute coronary syndromes (including unstable angina), coronary angioplasty or stenting, or bypass grafting.
Class III or IV heart failure as defined by the New York Heart Association functional classification system.
Known human immunodeficiency virus (HIV) infection, unless the participant can meet all of the following criteria:

Established antiretroviral therapy for at least 4 weeks and HIV viral load <400 copies/mL within Screening Period.
CD4+ T-cell (CD4+) counts ≥350 cells/μL.
No history of acquired immune deficiency syndrome-defining opportunistic infections within the last 12 months.
Positive hepatitis C antibody test result or positive hepatitis C ribonucleic acid (RNA) test result at screening or within 3 months prior to first dose of study intervention unless the participant can meet the following criteria:

RNA test negative.
Successful antiviral treatment (usually 8 weeks duration) is required, followed by a negative hepatitis C viral load RNA test after a washout period of at least 4 weeks.
Participants with hepatitis B will be excluded unless the defined criteria can be met.
Current corneal epithelial disease except for mild punctate keratopathy.
Intolerance or contraindications to antiviral prophylaxis.
Unable to tolerate antithrombotic prophylaxis.
Known immediate or delayed hypersensitivity reaction or idiosyncratic reaction to drugs chemically related to belantamab mafodotin, or any of the components of the study intervention.
Plasmapheresis within 7 days prior to the first dose of study intervention.
Participants must not have received a live or live-attenuated vaccine within 30 days prior to first dose of belantamab mafodotin.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation: Randomized
Model: Parallel assignment
Masking: Open label
Primary purpose: Treatment