Zanubrutinib Plus Rituximab as Front-line Treatment for Mucosa-associated Lymphoid Tissue Lymphoma (MALT)

Official title

Zanubrutinib Plus Rituximab as Front-line Treatment for Mucosa-associated Lymphoid Tissue Lymphoma (MALT): a Single-arm, Open-label, Multicenter, Phase II Study（ZAMA）

Overview

This is a prospective, single-arm, multicenter, phase II clinical trial to evaluate the efficacy and safety of Zanubrutinib in combination with Rituximab as a first-line treatment for patients with mucosa-associated lymphoid tissue (MALT) extranodal marginal zone lymphoma.

Detailed description

The purpose of this study is to evaluate the efficacy and safety of Zanubrutinib in combination with Rituximab as a first-line treatment for patients with mucosa-associated lymphoid tissue (MALT) extranodal marginal zone lymphoma.

Treatrment:

1. Rituximab: 375 mg/m², administered once a week in Cycle 1 (C1) and on Day 1 (D1) of Cycles 2-6 (C2-C6). 2. Zanubrutinib: 160 mg, administered twice daily from Day 1 to Day 28 (D1-D28). Each cycle lasts 28 days. After 6 cycles of treatment, patients who achieve complete remission (CR) will end treatment and enter observation follow-up. Patients with partial remission (PR) or stable disease (SD) will receive 2 additional cycles.

The primary study endpoint is the complete remission rate of Zanubrutinib in combination with Rituximab in the treatment of newly diagnosed mucosa-associated lymphoid tissue (MALT) extranodal marginal zone lymphoma.

Interventions

• Drug Zanubrutinib
  160 mg, administered twice daily from Day 1 to Day 28 (D1-D28)
• Drug Rituximab
  375 mg/m², administered once a week during Cycle 1 (C1), and on Day 1 (D1) of Cycles 2-6 (C2-C6)

Primary outcome measures

• Complete Response(CR) [Time frame: Up to 8 cycles (each cycle is 28 days)]

Secondary outcome measures (6)

• Objective response rate(ORR) [Time frame: Up to 8 cycles (each cycle is 28 days)]
• Progression-free survival(PFS) [Time frame: From the date of enrollment until the date of the first documented progression or date of death from any cause, whichever came first, assessed up to 24 months]
• Event-free survival(EFS) [Time frame: The proportion of patients without disease progression, treatment discontinuation, or death for any reason since enrollment, assessed up to 24 months]
• Overall survival(OS) [Time frame: From the date of enrollment until the date of death from ant cause, assessed up to 24 months]
• Duration of Response(DOR) [Time frame: The time from the patient's first efficacy assessment achieving CR or PR until disease progression, assessed up to 24 months]
• Time to Response(TTR) [Time frame: The time from the start of patient enrollment in the trial to the first efficacy assessment achieving CR or PR, assessed up tp 24 months]

Eligibility criteria

Inclusion criteria

• Mucosa-associated lymphoid tissue (MALT) extranodal marginal zone lymphoma confirmed by histopathology.
• Newly diagnosed with Ann Arbor stage III-IV or relapsed MALT after local treatment .
• No prior systemic anti-lymphoma therapy (except for H. pylori eradication therapy in H. pylori-positive gastric MALT patients).
• No histopathological transformation to high-grade lymphoma.
• At least one measurable lesion according to the Lugano 2014 criteria.

7\. Age ≥ 18 years, with no gender restrictions. 7. An ECOG performance status score of 0-2. 8. An expected survival time of more than 12 months. 9. Adequate bone marrow, cardiac, pulmonary, liver, and kidney function. 10. Willing to participate in the clinical study; fully informed and aware of the study, having signed the informed consent form; willing and able to comply with all study procedures.

Exclusion criteria

• Patients with a history of stroke, intracranial hemorrhage, or warfarin use within the past 6 months.
• Patients with central nervous system involvement.
• Patients who have undergone allogeneic hematopoietic stem cell transplantation in the past.
• Patients who have previously used BTK inhibitors or received CD20 monoclonal antibody therapy.

5, Patients with active infections, except for tumor-related B-symptom fever. 6. Patients with a concurrent history of other malignancies, except for cured cervical carcinoma in situ or basal cell carcinoma of the skin.

7\. Patients receiving potent cytochrome P450 inhibitors. 8. Patients with severe cardiovascular diseases, such as uncontrolled or symptomatic arrhythmias, congestive heart failure, or a history of myocardial infarction within the past 12 months.

9\. Patients, as judged by the investigator, who have significant organ dysfunction or uncontrollable comorbidities that pose a safety risk, or who have absorption and metabolism issues with Zanubrutinib.

10\. Pregnant or breastfeeding women and women of childbearing age unwilling to use contraception.

11\. Patients who have received anti-tumor therapy within 4 weeks prior to enrollment.

12\. Patients with active chronic hepatitis B or active hepatitis C. 13. Patients who have received systemic corticosteroid treatment or other immunosuppressive therapy within 14 days prior to the start of study treatment.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation

N/A

Model

Single group

Masking

Open label

Primary purpose

Treatment

Study locations

China · 1 center

• Sun Yat-sen Universitiy Cancer Center, Sun Yat-Sen University — Guangzhou

Identifiers

NCT: NCT06647732 · B2024-594-01

Primary sources (government registries)

• ClinicalTrials.gov (US NIH)

View this study on ClinicalTrials.gov ↗