Study of the Causal Link Between Rheumatoid Arthritis and Periodontitis Using Mendelian Randomization
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Rheumatoid Arthritis, Periodontitis. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Causal Association Between Rheumatoid Arthritis and Periodontitis: A Mendelian Randomization Study
Overview
This study aims to investigate the causal relationship between rheumatoid arthritis and periodontitis using Mendelian randomization. Data will be sourced from genome-wide association studies (GWAS) to explore genetic associations and assess potential risk factors in an East Asian population.
Detailed description
The purpose of this study is to explore the causal association between rheumatoid arthritis (RA) and periodontitis using Mendelian randomization (MR). RA and periodontitis share similar inflammatory pathways and immune responses, but their causal relationship remains unclear. This study will utilize genome-wide association studies (GWAS) data from an East Asian population to identify single nucleotide polymorphisms (SNPs) associated with RA and assess their potential impact on the risk of developing periodontitis. Statistical methods such as inverse-variance weighting, MR-Egger regression, and weighted median analysis will be employed to analyze the data. The findings may provide insights into the shared genetic basis and causal relationships between these two conditions, offering potential targets for preventive strategies.
Primary outcome measures
- Causal Association Between Rheumatoid Arthritis and Periodontitis [Time frame: Data collected from 2023 to 2024.]
Secondary outcome measures (1)
- Analysis of Genetic Pleiotropy and Confounders [Time frame: 2023 to 2024]
Eligibility criteria
Inclusion criteria
- Participants included in the genome-wide association study (GWAS) database.
- Subjects with available genotypic data relevant to rheumatoid arthritis and periodontitis.
Exclusion criteria
- Individuals without complete genotypic data or those with missing critical phenotypic information.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Other
Study locations
Center list to be confirmed — check the primary protocol.
Publications
- Li X, Ouyang Y, Liang L, Li Y. Causal association between rheumatoid arthritis and periodontitis: A Mendelian randomization study. Medicine (Baltimore). 2026 Jun 5;105(23):e49095. doi: 10.1097/MD.0000000000049095. PMID 42260828
Identifiers
NCT: NCT06603207 · KY20240918-01