PEEP Titration and Lung Recruitment Potential Assessed by 3D EIT
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In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: lung recruitment potential assessed by 3D EIT, PEEP titration by 3D eit.
- Who it may be relevant to
- Registry conditions: ARDS, Respiratory Failure. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
PEEP Titration and Lung Recruitment Potential Assessment by 3D EIT in ARDS Patients
Overview
In a population of ARDS patients, we explore the influence of different PEEP levels on regional ventilation distribution, ventilation homogeneity, and the center of ventilation, optimal PEEP and lung recruitment potential as well as the extent of lung collapse and overdistension as detected by 3D-EIT.
Interventions
- Procedure lung recruitment potential assessed by 3D EIT
Patients were ventilated based on the ARDS-Net suggestions. The patients were kept at supine position. The lung recruitment potential assessed by 3D EIT was as follows: 1. All patients were under pressure control mode (driving pressure 12-15 cmH2O with a tidal volume of 6-8 ml/kg predicted body weight, respiration rate12-15 bpm). 2. PEEP was switched to a zero end-expiratory pressure (ZEEP) for 10 min, and FiO2 was titrated to obtain peripheral oxygen saturation (SpO2 ) \> 90%. 3. PEEP was s - Procedure PEEP titration by 3D eit
Patients were ventilated based on the ARDS-Net suggestions. The patients were kept at supine position. The PEEP titriatino by 3D EIT fwas as follows: 1. All patients were under pressure control mode (driving pressure 12-15 cmH2O with a tidal volume of 6-8 ml/kg predicted body weight, respiration rate12-15 bpm). 2. RM: PEEP was switched to a 21cmH2O for 2min, and FiO2 was titrated to obtain peripheral oxygen saturation (SpO2 ) ≥90%. 3. PEEP was stepwise decrease from 21 to 0 cmH2O PEEP in steps
Primary outcome measures
- OD/CL and optimal PEEP monitored by EIT [Time frame: 5-10min]
Secondary outcome measures (4)
- ventilation distribution monitored by EIT [Time frame: 5-10min]
- GI monitored by EIT [Time frame: 5-10min]
- CoV monitored by EIT [Time frame: 5-10min]
- V/Q monitored by EIT [Time frame: 5-10min]
Eligibility criteria
Inclusion criteria
- patients on mechanical ventilation.
- Diagnosis of ARDS was based on the Berlin definition
- lung recruitment potential assessment and PEEP titration was proper for the ARDS patients determined by the attending doctor
Exclusion criteria
- Under 18 years of age.
- Pregnant women;
- Ribcage malformation
- Any contraindication to the use of EIT (e.g. automatic implantable cardioverter defibrillator, and implantable pumps).
- Hemodynamic instability, unable to tolerate high PEEP;
- High-risk individuals with pneumothorax, mediastinal emphysema, etc.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union — Beijing
Identifiers
NCT: NCT06594601 · PEEP by 3D-EIT for ARDS · PUMCH