Testicular Function and Semen Quality in Male Childhood and Adolescent Cancer Survivors
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Hormonal profile, Semen analysis, Questionnaire.
- Who it may be relevant to
- Registry conditions: Cancer, Treatment-Related, Late Effect, Semen Analysis. Basic parameters: 18 years — 50 years · Male.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Effect of Cancer Treatment on Testicular Function and Semen Quality in Male Childhood and Adolescent Cancer Survivors
Overview
Cancer treatment can affect the testicular function, including sperm and hormonal functions. The aim of this study is to assess the testicular function and semen quality in young men who recover from childhood and adolescent cancer in Hong Kong. This can provide more information for pre-treatment counselling as well as improve post treatment survivorship care. The testicular function will be compared to aged-matched controls from men attending the Family Planning Association for premarital check-up.
Detailed description
This is a cohort observational study. The target population for the trial will be men who have received chemotherapy and/ or radiotherapy for cancer diagnosed when they were \< 18 years old, currently \> 18 years old to 50 years old and cancer in remission for at least 2 years. The testicular function, including sperm and hormonal functions, will be compared with aged-matched controls from men attending the Family Planning Association for premarital check-up.
Interventions
- Other Hormonal profile
Blood for FSH, LH, testosterone - Other Semen analysis
Semen analysis - Other Questionnaire
The European Male Ageing Study (EMAS) questionnaire
Primary outcome measures
- Sperm concentration [Time frame: up to 3 months]
Secondary outcome measures (1)
- Semen parameters [Time frame: up to 3 months]
Eligibility criteria
Inclusion criteria
- Men who have received chemotherapy and/ or radiotherapy for cancer diagnosed when they were < 18 years old.
- > 18 years old to 50 years old
- Cancer in remission for at least 2 years
Exclusion criteria
- Unable to ejaculate by masturbation to provide semen samples
- Cryptorchidism, testicular cancer, history of vasectomy
- On testosterone replacement therapy
- Refusal to join the study
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-control
Study locations
China · 1 center
- Queen Mary Hospital — Hong Kong
Identifiers
NCT: NCT06587477 · UW21-038