A Trial to Evaluate Intravesical Nadofaragene Firadenovec Alone or in Combination With Chemotherapy or Immunotherapy in Participants With High-grade BCG Unresponsive Non-muscle Invasive Bladder Cancer

Official title

A Phase 3, Randomised, Multi-center, Open Label Trial to Evaluate the Safety and Efficacy of Intravesical Nadofaragene Firadenovec Alone or in Combination With Chemotherapy or Immunotherapy in Participants With High-grade Bacillus Calmette-Guerin Therapy (BCG) Unresponsive Non-muscle Invasive Bladder Cancer (NMIBC)

Overview

The pivotal phase 3 trial (rAd-IFN-CS 003) evaluating the efficacy of nadofaragene firadenovec showed that 55 (53.4%) of 103 subjects with CIS ± high-grade Ta/T1 achieved a complete response (CR) at 3 months. In this trial, the safety and efficacy of intravesical instillation of nadofaragene firadenovec alone or in combination with chemotherapy or immunotherapy will be evaluated in participants with NMIBC CIS (± high-grade Ta/T1).

Interventions

• Drug Nadofaragene Firadenovec
  vector-based gene therapy for NMIBC treatment to potentiate durable therapeutic responses by interferon (IFN) alfa-2b (IFN-α2b) amplification. It is a non-replicating recombinant adenovirus serotype 5 vector containing a transgene encoding the human IFN-α2b gene.
• Drug Gemcitabine
  Intravesical Gemcitabine chemotherapy, used in combination with Docetaxel.
• Drug Docetaxel
  Intravesical Docetaxel chemotherapy, used in combination with Gemcitabine.
• Drug Pembrolizumab
  Pembrolizumab is an FDA approved immune checkpoint inhibitor which restores the anti-tumour immune response by blocking the programmed cell death protein 1 (PD-1). Pembrolizumab is administered via intravenous (IV) infusion.

Primary outcome measures

• Complete response [Time frame: up to 6 months]

Secondary outcome measures (9)

• Complete response at month 3 [Time frame: 3 months]
• Complete response at month 6 [Time frame: 6 months]
• Durability of complete response [Time frame: Up to 24 months]
• Muscle-invasive progression of disease [Time frame: up to 36 months]
• Cystectomy-free survival [Time frame: up to 36 months]
• Pathological staging [Time frame: up to 36 months]
• Overall survival [Time frame: up to 36 months]
• Evidence of malignant lesions of the upper tract and/or prostatic urethra [Time frame: up to 24 months]
• Adverse events [Time frame: up to 36 months]

Eligibility criteria

Inclusion criteria

• Diagnosed, as documented, with carcinoma in situ (CIS) ±Ta/T1 high-grade disease.

• For T1 disease biopsies should contain muscle fibres.
• Unresponsive to ≥2 courses of Bacillus Calmette-Guerin (BCG) therapy within the last 12 months. BCG-unresponsive refers to participants with high-grade non-muscle invasive bladder cancer (NMIBC) who are unlikely to benefit from and who will not be receiving further intravesical BCG. The term "BCG-Unresponsive" includes participants who did not respond to BCG treatment and have a persistent high-grade recurrence within 12 months after BCG was initiated, and those who despite an initial complete response to BCG, relapse with CIS within 12 months of their last intravesical treatment with BCG or relapse with high-grade Ta/T1 NMIBC within 6 months of their last intravesical treatment with BCG. The following criteria define the participants who may be included in the trial:

• Have received at least 2 courses of BCG within a 12 month period - defined as at least 5 of 6 induction BCG instillations and at least 2 of 3 instillations of maintenance BCG, or at least 2 of 6 instillations of a second induction course, where maintenance BCG is not given.

o Exception: those who have T1 high-grade disease at 1st evaluation after induction BCG alone (at least 5 of 6 doses) may qualify in the absence of disease progression

• At the time of tumour recurrence, participants with CIS alone or high-grade Ta/T1 with CIS should be within 12 months of last exposure to BCG
• No maximum limit to the amount of BCG administered
• All visible papillary tumours must be resected and those with persistent T1 disease on transurethral resection of bladder tumour (TURBT) should undergo an additional re-TURBT within 14 to 70 days prior to beginning trial treatment. Obvious areas of CIS should also be fulgurated
• Eastern Cooperative Oncology Group (ECOG) status ≤2
• Aged ≥18 years at the time of consent
• Available for the whole duration of the trial
• Life expectancy >2 years, in the opinion of the investigator
• Absence of concomitant upper tract urothelial carcinoma or urothelial carcinoma within the prostatic urethra. Freedom from upper tract disease (if clinically indicated) as indicated by no evidence of upper tract tumour by either intravenous pyelogram, retrograde pyelogram, computed tomography (CT) scan with or without urogram, or magnetic resonance imaging (MRI) with or without urogram performed within 6 months of enrolment. Absence of locally advanced disease as assessed by CT scan or MRI
• Participants who elect not to undergo cystectomy
• Participants with prostate cancer on active surveillance at low risk for progression are permitted to be included into the trial at the discretion of the investigator
• Females of reproductive potential must have a negative highly sensitive urine or serum pregnancy test upon entry into this trial and be willing to use highly effective contraception during treatment with the investigational medicinal product and for 6 months following the last dose. Otherwise, female participants must be post-menopausal (no menstrual period for a minimum of 12 months, as confirmed by follicle-stimulating hormone levels) or surgically sterile
• Male subjects must be willing to use a male condom and effective contraception during sex throughout the treatment period and for 3 months following the last dose.

Exclusion criteria

• Current or previous evidence of muscle-invasive (muscularis propria) or metastatic disease presented at the screening visit. Examples of increased risk of muscle-invasive disease include but are not limited to:

• Presence of lymphovascular invasion and / or micropapillary, sarcomatoid, plasmacytoid and / or neuroendocrine disease as shown in the histology of the biopsy sample
• Participants with CIS+T1 disease accompanied by the presence of hydronephrosis secondary to the primary tumour
• Current systemic therapy for bladder cancer other than investigational medicinal products used in randomisation arm
• Current or prior investigational treatment for BCG-unresponsive NMIBC or any other investigational drug (drug used in a clinical trial, i.e drug used in a Ferring sponsored non interventional study does not apply) within 1 month prior to screening
• Current or prior pelvic external beam radiotherapy within 2 years of screening
• Prior treatment with nadofaragene firadenovec at any time
• Prior systemic therapy for bladder cancer at any time
• Prior intravesical chemotherapy for the treatment of BCG-unresponsive NMIBC

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation

Randomized

Model

Parallel assignment

Masking

Open label

Primary purpose

Treatment

Study locations

United States · 39 centers

• Center for Neurosciences — Tucson
• Arkansas Urology, North Little Rock — Little Rock
• American Institute of Research — Los Angeles
• USC Kenneth Norris Jr Cancer Hospital — Los Angeles
• University of California, Irvine — Orange
• Genesis Research, LLC - San Diego — San Diego
• Advent Health — Denver
• Colorado Urology - St. Anthony Hospital Campus — Lakewood
• … and 31 more centers

Spain · 13 centers

• Instituto de Investigacion Valdecilla (IDIVAL) / Hospital universitario Marques de Valdeci — Santander
• Hospital del Mar — Barcelona
• Hospital Clinic De Barcelona - University of Barcelona — Barcelona
• Hospital Universitario Reina Sofia — Córdoba
• Hospital Universitario de A Coruna — A Coruña
• Hospital Universitario Fundacion Alcorcon — Alcorcón
• Clinica Universidad de Navarra - Madrid — Madrid
• Hospital Universitario 12 De Octubre (Madrid) — Madrid
• … and 5 more centers

France · 9 centers

• CHU Clermont Ferrand - Hopital Gabriel Montpied — Clermont-Ferrand
• Hospices Civils de Lyon - Edouard Herriot Hosp. — Lyon
• CHU Toulouse - Hopital Rangueil — Toulouse
• CHU Nantes - Hotel Dieu — Nantes
• CHU de Bordeaux - Hôpital Pellegrin — Bordeaux
• Centre Hospitalier Universitaire De Nimes (Nîmes) — Nîmes
• Centre Hospitaliser Universitaire de Lyon Sud — Lyon
• Hopital La Pitie Salpetriere — Paris
• … and 1 more center

Czechia · 5 centers

• Krajska Nemocnice Liberec — Liberec
• Fakultní Thomayerova Nemocnice — Prague
• Fakultni nemocnice v Motole — Prague
• Androgeos, spol. s r.o. — Prague
• Kromerizska Nemocnice A S — Kroměříž

South Korea · 4 centers

• Pusan National University Yangsan Hospital — Yangsan
• Korea University Anam Hospital — Seoul
• Samsung Medical Center — Seoul
• Seoul National University Hospital — Seoul

Canada · 3 centers

• Prostate Cancer Centre — Calgary
• University Health Network UHN - Princess Margaret Cancer Centre — Toronto
• Centre Hospitalier de L'Universite de Montreal — Montreal

Poland · 3 centers

• IN-VIVO Bydgoszcz — Bydgoszcz
• Clinical Research Center Spółka z ograniczoną odpowiedzialnością Medic-R Sp.k. — Poznan
• Medical Concierge Centrum Medyczne — Warsaw

Identifiers

NCT: NCT06545955 · 000434 · U1111-1299-0176

Primary sources (government registries)

• ClinicalTrials.gov (US NIH)

View this study on ClinicalTrials.gov ↗