Speech Motor Learning and Retention (Aim 3)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: fMRI, Adaptation, Adaptation.
- Who it may be relevant to
- Registry conditions: Speech. Basic parameters: 18 years — 40 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Sensorimotor Basis of Speech Motor Learning and Retention
Overview
The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well. The strategy for the proposed research is to identify individual brain areas that contribute causally to retention by disrupting their activity with transcranial magnetic stimulation (TMS). Investigators will also use functional magnetic resonance imaging (fMRI) which will enable identification of circuit-level activity which predicts either learning or retention of new movements, and hence test the specific contributions of candidate sensory and motor zones. In other studies, investigators will record sensory and motor evoked potentials over the course of learning to determine the temporal order in which individual sensory and cortical motor regions contribute. The goal here is to identify brain areas in which learning-related plasticity occurs first and which among these areas predict subsequent learning.
Detailed description
The focus of this registration is Aim 3. Excitability will be assessed. In Aim 3, resting-state fMRI will be interleaved with speech motor adaptation, again using Harvard Sentences. Additional scans and retention tests will be conducted 24 hours later, to assess motor memory consolidation.
The Speech Motor Learning and Retention Master Protocol is NCT06467292.
Interventions
- Device fMRI
To assess functional connectivity patterns between regions that predict learning. - Behavioral Adaptation
Auditory adaptation in speech - Behavioral Adaptation
Auditory baseline in speech
Primary outcome measures
- Speech motor learning [Time frame: Performance as measured at the end of learning (30 minute session)]
- Retention of learning [Time frame: 24 hours after learning (re-test lasts 30 minutes)]
- Change in fMRI resting-state connectivity following speech motor learning [Time frame: baseline and at the end of learning (30 minute session)]
- fMRI resting-state connectivity measures of motor memory retention [Time frame: 24 hours after learning (re-test lasts 30 minutes)]
Eligibility criteria
Inclusion criteria
- Fluent English speakers
- Right-handed
- Normal hearing
- No speech disorder or reading disability
Exclusion criteria
- Cardiac pacemaker
- Aneurysm clip
- Heart or Vascular clip
- Prosthetic valve
- Metal implants
- Metal in brain, skull, or spinal cord
- Implanted neurostimulator
- Medication infusion device
- Cochlear implant or tinnitus (ringing in ears)
- Personal and/or family history of epilepsy or other neurological disorders or history of head concussion
- Psychoactive medications
- Pregnancy
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
United States · 1 center
- Yale Child Study Center — New Haven
Identifiers
NCT: NCT06492252 · 2000037622_c · 1R01DC022097-01A1