Predicting Responses to Exhausting, Prolonged, And Repeated Exercise Demands (PREPARED) for Heat
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: 30/30 work/rest cycle, 30/20 work/rest cycle, 40/30 work/rest cycle, 20/12 work/rest cycle.
- Who it may be relevant to
- Registry conditions: Hyperthermia, Fatigue; Heat. Basic parameters: 18 years — 39 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The overall goal of this project is to identify a work/rest cycle that allows for faster mission completion needed in emergency situations, compared to current Army heat guidance, while mitigating heat strain and neuromuscular fatigue. This project will determine the trade-off between faster mission completion and risk of heat strain and physical performance decrements. Completion of this project will allow military leaders to make informed decisions by understanding the impact of their choices on the magnitude of physical performance decrements and expected heat casualties, setting up hot weather missions for success.
Interventions
- Other 30/30 work/rest cycle
Participants will walk on a treadmill while wearing a weighted backpack to a work/rest cycle of 30 minutes of work followed by 30 minutes of rest. - Other 30/20 work/rest cycle
Participants will walk on a treadmill while wearing a weighted backpack to a work/rest cycle of 30 minutes of work followed by 20 minutes of rest. - Other 40/30 work/rest cycle
Participants will walk on a treadmill while wearing a weighted backpack to a work/rest cycle of 40 minutes of work followed by 30 minutes of rest. - Other 20/12 work/rest cycle
Participants will walk on a treadmill while wearing a weighted backpack to a work/rest cycle of 20 minutes of work followed by 12 minutes of rest.
Primary outcome measures
- Core temperature [Time frame: 180 minutes of work]
- Isometric mid-thigh pull strength [Time frame: 180 minutes of work]
Secondary outcome measures (4)
- Metabolic cost [Time frame: 180 minutes of work]
- Heart rate [Time frame: 180 minutes of work]
- Mean skin temperature [Time frame: 180 minutes of work]
- Vastus lateralis electromyography [Time frame: 180 minutes of work]
Eligibility criteria
Inclusion criteria
- Healthy individuals
- Physically active
Exclusion criteria
- History of cardiovascular, metabolic (such as clinical thyroid disease), respiratory, neural, or renal disease
- Hypertensive (systolic blood pressure > 139 mmHg, diastolic blood pressure > 89 mmHg) or tachycardic (heart rate > 100 bpm) during the screening visit
- Taking medications or supplements known to effect physiologic responses to exercise or thermoregulation (e.g., beta blockers, omega-3 fatty acids, statins, aspirin)
- Tobacco or nicotine use currently or in the past six months
- Musculoskeletal injury expected to impact exercise in the protocol
- A positive pregnancy test at any point in the study
- Study physician discretion based on any other medical condition or medication
- Inability to understand or follow instructions or the protocol
- Gastrointestinal disease or previous surgery prohibiting core temperature capsule use. Participants with a contraindication can opt to insert the pill rectally as a suppository.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Open label
- Primary purpose
- Prevention
Study locations
United States · 1 center
- Center for Research and Education in Special Environments — Buffalo
Identifiers
NCT: NCT06475339 · STUDY00007981 · CDMRP-BA230031