Predicting Responses to Exhausting, Prolonged, And Repeated Exercise Demands (PREPARED) for Heat

Обзор

The overall goal of this project is to identify a work/rest cycle that allows for faster mission completion needed in emergency situations, compared to current Army heat guidance, while mitigating heat strain and neuromuscular fatigue. This project will determine the trade-off between faster mission completion and risk of heat strain and physical performance decrements. Completion of this project will allow military leaders to make informed decisions by understanding the impact of their choices on the magnitude of physical performance decrements and expected heat casualties, setting up hot weather missions for success.

Вмешательства

• Другое 30/30 work/rest cycle
  Participants will walk on a treadmill while wearing a weighted backpack to a work/rest cycle of 30 minutes of work followed by 30 minutes of rest.
• Другое 30/20 work/rest cycle
  Participants will walk on a treadmill while wearing a weighted backpack to a work/rest cycle of 30 minutes of work followed by 20 minutes of rest.
• Другое 40/30 work/rest cycle
  Participants will walk on a treadmill while wearing a weighted backpack to a work/rest cycle of 40 minutes of work followed by 30 minutes of rest.
• Другое 20/12 work/rest cycle
  Participants will walk on a treadmill while wearing a weighted backpack to a work/rest cycle of 20 minutes of work followed by 12 minutes of rest.

Первичные конечные точки

• Core temperature [Срок оценки: 180 minutes of work]
• Isometric mid-thigh pull strength [Срок оценки: 180 minutes of work]

Вторичные конечные точки (4)

• Metabolic cost [Срок оценки: 180 minutes of work]
• Heart rate [Срок оценки: 180 minutes of work]
• Mean skin temperature [Срок оценки: 180 minutes of work]
• Vastus lateralis electromyography [Срок оценки: 180 minutes of work]

Критерии участия

Критерии включения

• Healthy individuals
• Physically active

Критерии исключения

• History of cardiovascular, metabolic (such as clinical thyroid disease), respiratory, neural, or renal disease
• Hypertensive (systolic blood pressure > 139 mmHg, diastolic blood pressure > 89 mmHg) or tachycardic (heart rate > 100 bpm) during the screening visit
• Taking medications or supplements known to effect physiologic responses to exercise or thermoregulation (e.g., beta blockers, omega-3 fatty acids, statins, aspirin)
• Tobacco or nicotine use currently or in the past six months
• Musculoskeletal injury expected to impact exercise in the protocol
• A positive pregnancy test at any point in the study
• Study physician discretion based on any other medical condition or medication
• Inability to understand or follow instructions or the protocol
• Gastrointestinal disease or previous surgery prohibiting core temperature capsule use. Participants with a contraindication can opt to insert the pill rectally as a suppository.

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Распределение

Рандомизированное

Модель

Перекрёстный дизайн

Маскирование

Открытое

Основная цель

Профилактика

Центры проведения

США · 1 центр

• Center for Research and Education in Special Environments — Buffalo

Идентификаторы

NCT: NCT06475339 · STUDY00007981 · CDMRP-BA230031

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗