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Recruiting NCT06450977

Remote Evaluation of MIND Diet

No phase Interventional Multiple Sclerosis Cognitive Change Nutrition, Healthy

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: MIND Diet, Control Diet.
Who it may be relevant to
Registry conditions: Multiple Sclerosis, Cognitive Change, Nutrition, Healthy. Basic parameters: 18 years — 64 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves thinking ability and memory compared to a healthy control diet in persons with Multiple Sclerosis (MS). The main question it aims to answer is: Does the MIND diet improve cognitive performance relative to a control diet in persons with MS? Participants will: Consume one meal that follows the MIND diet or a control meal every day for 3 months, complete online surveys and cognitive testing before and after, and keep a record of the food they eat during the study.

Detailed description

The purpose of this study is to understand how a healthy diet is related to thinking ability and memory in people with multiple sclerosis (MS). This study is fully remote consisting of meals being delivered to participant homes using Daily Harvest meal delivery service. Participants will be asked to consume a microwaveable study meal or prepackaged smoothie every day for 12 weeks. The study meals and smoothies will follow either a dietary pattern thought to improve brain health (Mediterranean-DASH Intervention for Neurodegenerative Delay; MIND), or a control diet, and will include foods commonly found in grocery stores. Participants will not know which diet they are assigned to (active or control). Participants will also be asked to follow simple dietary guidance on a healthy diet in addition to the meals provided. Participants will complete a series of online forms or surveys. Additionally, participants will complete an online cognitive battery from Cambridge Neuropsychological Test Automated Battery (CANTAB) at the beginning and end of the study.

Interventions

  • Other MIND Diet
    Daily meals designed to increase adherence to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) dietary pattern.
  • Other Control Diet
    Daily meals designed to increase fruit, vegetable, and whole grain intake consistent with a healthy American diet.

Primary outcome measures

  • Information Processing [Time frame: 12 weeks (Baseline vs. Follow Up)]
  • Visual Processing [Time frame: 12 weeks (Baseline vs. Follow Up)]
  • Processing Speed [Time frame: 12 weeks (Baseline vs. Follow Up)]
  • Learning [Time frame: 12 weeks (Baseline vs. Follow Up)]
  • Memory [Time frame: 12 weeks (Baseline vs. Follow Up)]
  • MIND Scores [Time frame: 12 weeks (Baseline vs. Follow Up)]
Secondary outcome measures (6)
  • Recruitment Rates [Time frame: Throughout the recruitment process]
  • Refusal Rates [Time frame: Throughout the recruitment process.]
  • Retention rates [Time frame: Throughout the intervention (weeks 1-12)]
  • Attrition rates [Time frame: Throughout the intervention (weeks 1-12)]
  • Adherence/Compliance Rates [Time frame: Throughout the intervention (weeks 1-12)]
  • Participant Experience and Burden [Time frame: Throughout the intervention (weeks 1-12)]

Eligibility criteria

Inclusion criteria

  • Individuals aged 18-64 years old
  • Self-reported diagnosis of Multiple sclerosis (MS)
  • 20/20 or corrected vision
  • No other neurodegenerative disease diagnosis
  • Stable disease-modifying therapy (DMT) within 6 months
  • Not Pregnant or lactating
  • No food allergies or intolerances
  • Able to consume study meals
  • Not enrolled in another dietary, exercise, or medication study during the study
  • Access to a computer/laptop with internet

Exclusion criteria

  • Individuals younger than 18 or older than 64 years old
  • No self-reported diagnosis of Multiple sclerosis (MS)
  • Not 20/20 or uncorrected vision
  • Other neurodegenerative disease diagnosis
  • Disease modifying therapy (DMT) less than 6 months
  • Pregnant or lactating
  • Food allergies or intolerances
  • Not able to consume study meals
  • Enrolled in another dietary, exercise, or medication study during the study
  • No access to a computer/laptop with internet

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Single blind
Primary purpose
Supportive care

Study locations

United States · 1 center
  • University of Illinois Urbana-Champaign — Urbana

Publications

  • Martell SG, Holthaus TA, Verma S, Adamson B, Motl RW, Khan NA. Mediterranean-DASH intervention for neurodegenerative delay (MIND) diet intervention in persons with multiple sclerosis: A feasibility, randomized controlled trial. Nutr Res. 2026 May 28;152:11-25. doi: 10.1016/j.nutres.2026.05.006. Online ahead of print. PMID 42314522

Identifiers

NCT: NCT06450977 · REMIND

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗