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Virtual Reality Cognitive Training for Older Adults With Mild Cognitive Impairment

No phase Interventional Mild Cognitive Impairment Older Adults

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: fi-VR Cognitive Training, Traditional Cognitive Training.
Who it may be relevant to
Registry conditions: Mild Cognitive Impairment, Older Adults. Basic parameters: 65 years — 90 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Center list to be confirmed — check the primary protocol.
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Effects of Fully Immersive Virtual Reality Cognitive Training Based on Instrumental Activities of Daily Living for Older Adults With Mild Cognitive Impairment

Overview

This study aims to (1) develop and assess the feasibility of a fi-VRCT program based on IADL for older adults with MCI, (2) implement and evaluate the effectiveness of the fi-VRCT program based on IADL in older adults with MCI, and (3) investigate the potential mechanism of the fi-VRCT program based on IADL for older adults with MCI and refine this intervention accordingly.

Detailed description

As research on cognitive training methods for older adults with mild cognitive impairment (MCI) progresses, fully immersive virtual reality cognitive training (fi-VRCT) has emerged as a promising approach. While the benefits of fi-VRCT for enhancing cognitive function have been recognized, its potential to improve instrumental activities of daily living (IADL) and promote independence remains uncertain. This study addresses these questions by developing and validating a fi-VRCT program based on IADL to enhance cognitive and IADL performance among older adults with MCI.

Interventions

  • Behavioral fi-VR Cognitive Training
    All participants will 16 sessions over eight weeks, with two sessions per week, each lasting 70 minutes. Participants in the fi-VRCT will use the virtual reality system with head-mounted display and handheld controllers. The fi-VRCT will be administered by an experienced research assistant.
  • Behavioral Traditional Cognitive Training
    All participants will 16 sessions over eight weeks, with two sessions per week, each lasting 70 minutes. The CT control program will include cognitive board games designed to improve various cognitive capacities. Certified community occupational therapists will lead the CT control group.

Primary outcome measures

  • Changes scores of Montreal Cognitive Assessment (MoCA) [Time frame: At baseline, at week 9, and at 3-month follow-up.]
  • Change scores of Wechsler Memory Scale (WMS) [Time frame: At baseline, at week 9, and at 3-month follow-up.]
  • Change scores of Amsterdam Instrumental Activities of Daily Living Questionnaire, Short Version [Time frame: At baseline, at week 9, and at 3-month follow-up.]
  • Change scores of Lawton Instrumental Activities of Daily Living [Time frame: At baseline, at week 9, and at 3-month follow-up.]
Secondary outcome measures (2)
  • Change scores of Digit Span [Time frame: At baseline, at week 9, and at 3-month follow-up.]
  • Change scores of Stroop Color-Word Test [Time frame: At baseline, at week 9, and at 3-month follow-up.]

Eligibility criteria

Inclusion criteria

  • Aged 65 or above.
  • MoCA score between 18 and 25.
  • Capability to follow directions and do tasks.

Exclusion criteria

  • History of dementia.
  • Previous neurodegenerative illness diagnosis.
  • Severe medical or surgical problems.
  • Major psychological disorders.
  • Inability to use VR system

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Double blind
Primary purpose
Treatment

Study locations

Center list to be confirmed — check the primary protocol.

Publications

  • Chen IC, Wu CY, Hu YL, Huang YM. Development and Validation of Virtual Reality Cognitive Training for Older Adults with Mild Cognitive Impairment: Protocol for a Mixed-Methods Program Evaluation Study. Clin Interv Aging. 2024 Nov 9;19:1855-1865. doi: 10.2147/CIA.S471547. eCollection 2024. PMID 39539569

Identifiers

NCT: NCT06392412 · DaYehU

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗