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Not yet recruiting NCT06315504

Circulating Factors in Nephrotic Syndrome

— Observational Nephrotic Syndrome Membranous Nephropathy Minimal Change Disease Primary Focal Segmental Glomerulosclerosis

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Observation.
Who it may be relevant to
Registry conditions: Nephrotic Syndrome, Membranous Nephropathy, Minimal Change Disease, Primary Focal Segmental Glomerulosclerosis. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Center list to be confirmed — check the primary protocol.
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Circulating Factors in Nephrotic Syndrome - A Prospective Observational Cohort Study

Overview

A prospective observational study to investigate the treatment-associated changes of circulating factors associated with glomerular diseases among patients with de novo nephrotic syndrome admitted to hospital for a kidney biopsy.

Interventions

  • Other Observation
    Observation

Primary outcome measures

  • levels of anti-nephrin in blood by ELISA [Time frame: up to 12 months]
Secondary outcome measures (1)
  • changes in auto-antibodies in blood associated with membranous nephropathy [Time frame: up to 24 months]

Eligibility criteria

Inclusion criteria

  • Age ≥ 18 years
  • Plasma albumin < 36 g/L
  • Urine protein >3.5 g/day or urine protein/creatinine-ratio (UPCR) > 3.5 or urine albumin/creatinine-ratio (UACR) >2200 mg/g
  • Planned kidney biopsy
  • Able to give written informed consent

Exclusion criteria

  • Kidney transplant recipient
  • Previously undergone a kidney biopsy
  • Unable to understand written information in Danish

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Study design

Observational model
Cohort

Study locations

Center list to be confirmed — check the primary protocol.

Identifiers

NCT: NCT06315504 · Nephrotic Syndrome Cohort

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗