Recruiting NCT06196203
A Study of AK117 in Combination With Azacitidine in Patients With Myelodysplastic Syndromes
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: AK117, Placebo, Azacitidine.
- Who it may be relevant to
- Registry conditions: Higher-risk Myelodysplastic Syndromes. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States, China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
A Randomized, Double-blind, Placebo-controlled, Multicenter Phase 2 Study of AK117/Placebo in Combination With Azacitidine in Patients With Newly Diagnosed Higher-risk Myelodysplastic Syndromes
Overview
This is a Phase 2 randomized, double-blind, placebo-controlled, multicenter study evaluating the efficacy and safety of AK117 or placebo, combined with azacitidine in patients with newly diagnosed higher-risk myelodysplastic syndromes (HR-MDS).
Interventions
- Drug AK117
AK117 IV injection - Drug Placebo
Placebo IV injection - Drug Azacitidine
Azacitidine SC injection
Primary outcome measures
- Complete remission rate (CRR) [Time frame: Up to approximately 2 years]
Secondary outcome measures (10)
- Overall response rate (ORR) [Time frame: Up to approximately 2 years]
- Time to response (TTR) [Time frame: Up to approximately 2 years]
- Time to CR (TTCR) [Time frame: Up to approximately 2 years]
- Duration of response (DoR) [Time frame: Up to approximately 2 years]
- Duration of CR (DoCR) [Time frame: Up to approximately 2 years]
- Event-free survival (EFS) [Time frame: Up to approximately 2 years]
- Overall survival (OS) [Time frame: Up to approximately 2 years]
- Number of subjects with adverse events (AEs) [Time frame: Up to approximately 2 years]
- Pharmacokinetic characteristics [Time frame: Up to approximately 2 years]
- Anti-drug antibody (ADA) [Time frame: Up to approximately 2 years]
Eligibility criteria
Inclusion criteria
- Age ≥ 18 years old at the time of enrolment.
- Eastern Cooperative Oncology Group (ECOG) performance status score of 0 to 2.
- Expected life expectancy ≥ 3 months.
- Newly diagnosed HR-MDS, according to the 2016 World Health Organization (WHO) classification with the presence of < 20% blasts in bone marrow or peripheral blood; Overall IPSS-R score ≥ 3.5.
- Ability to undergo the study-required bone marrow sample collection procedures.
- Suitable venous access for the study-required blood sampling (i.e., including PK and immunogenicity).
- Female patients of childbearing age must have negative serum pregnancy test results before randomization or per region-specific guidance documented in the informed consent and a negative urine pregnancy test on the day of first dose prior to dosing.
- Female patients of childbearing potential having sex with an unsterilized male partner must agree to use a highly effective method of contraception from the beginning of screening until 180 days after the last dose of the study treatment.
- Unsterilized male patients having sex with a female partner of childbearing potential must agree to use an effective method of contraception from the beginning of screening until 180 days after the last dose of study treatment.
Exclusion criteria
- MDS evolving from a pre-existing myeloproliferative neoplasm (MPN), myelodysplastic/myeloproliferative neoplasms (MDS/MPN).
- Prior treatment with Cluster of Differentiation (CD) 47 or Signal-regulatory protein alpha (SIRPα)-targeting agents.
- Concurrently participating in another interventional clinical study, unless it is an observational (non-interventional) clinical study or during the follow-up period of an interventional study.
- Patients who previously diagnosed with another malignancy and have any evidence of residual disease.
- Known allergy to any component of any study drug; known history of severe hypersensitivity to other monoclonal antibodies.
- Patients with any psychiatric or social factor which the investigator deems may interfere with the patient's ability to comply with the requirements of the study.
- Patients with current hypertension with systolic blood pressure ≥ 160 mmHg or diastolic blood pressure ≥ 100 mmHg after oral antihypertensive therapy.
- Patients with known cardiopulmonary disease defined as unstable angina, clinically significant arrhythmia, congestive heart failure (New York Heart Association Class III or IV), decompensated cirrhosis, nephrotic syndrome, uncontrolled metabolic disorders.
- Patients who are breastfeeding or plans to breastfeed during the study.
- Other conditions where the investigator considers the patient inappropriate for enrollment.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Quadruple blind
- Primary purpose
- Treatment
Study locations
United States · 14 centers
- UCLA Ronald Reagan Medical Center — Los Angeles
- Rocky Mountain Cancer Centers — Aurora
- Yale Cancer Center — New Haven
- Mid Florida Hematology and Oncology Center — Orange City
- American Oncology Partners, PA (The Center for Cancer and Blood Disorders-Bethesda) — Bethesda
- Maryland Oncology-Columbia — Columbia
- Washington University School of Medicine in St. Louis — St Louis
- Montefiore Einstein Comprehensive Cancer Center — The Bronx
- … and 6 more centers
China · 1 center
- Institute of hematolongy&blood diseases hospital, chinese academy of medical sciences&peki — Tianjin
Identifiers
NCT: NCT06196203 · AK117-205