Persistent Post Surgical Pain After Total Knee Arthroplasty
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: continuous peripheral nerve block.
- Who it may be relevant to
- Registry conditions: Knee Arthropathy. Basic parameters: 18 years — 85 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Italy
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Enhanced Recovery After Surgery and Total Knee Replacement: A Prospective, Randomized Study on the Rule of Peripheral Nerve Blocks on Persistent Postoperative Pain Six Months After Surgery
Overview
Patients undergone total knee replacement are randomized to receive a "fast track" regional anesthesia protocol or a "traditional" regional anesthesia continuous infusion by both a femoral and sciatic catheter to assess if this latter technique may reduce persistent postoperative pain six months after surgery
Detailed description
Patients undergone to primary total knee replacement with spinal anesthesia are randomized to receive a continuous adductor canal block infusion + an ipack block or a continuous femoral nerve block + a continuous sciatic nerve block just at the end of surgery. Both group will receive a multimodal analgesia with paracetamol, ketorolac, desametasone and morphine as a rescue.
Interventions
- Procedure continuous peripheral nerve block
continuous regional anesthesia in total knee replacement
Primary outcome measures
- Persistent post surgical pain [Time frame: 0-6-month]
Secondary outcome measures (2)
- acute postoperative pain [Time frame: 0-72 hours]
- Morphine requirement [Time frame: 0-72 hours]
Eligibility criteria
Inclusion criteria
- primary total knee replacement with a written informed consent
Exclusion criteria
- Allergy to local anesthetics or any drugs involve in the study
- Controindication to regional anesthesia
- chronic use of opioids
- BMI > 35 kg m2
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Prevention
Study locations
Italy · 1 center
- Policlinico di Monza SPA — Monza
Identifiers
NCT: NCT06182059 · PPSP PTG