Comparing the Efficacy and Safety of Rezvilutamide+ADT+Docetaxel Versus Rezvilutamide +ADT in the mHSPC
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Docetaxel, Rezvilutamide.
- Who it may be relevant to
- Registry conditions: Metastatic Prostate Cancer, Hormone Sensitive Prostate Cancer, Chemotherapy Effect. Basic parameters: 40 years — 80 years · Male.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
A Prospective Randomized Controlled Study Comparing the Efficacy and Safety of Rezvilutamide+ADT+Docetaxel Versus Rezvilutamide +ADT in the Treatment of Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC)
Overview
Evaluate whether the combination of Rezvilutamide and androgen deprivation therapy (ADT) with docetaxel improves overall survival (OS) in patients with metastatic hormone-sensitive prostate cancer (mHSPC) compared to the combination of Rezvilutamide and ADT.
Detailed description
To investigate the value of chemotherapy in the treatment of high-burden of mHSPC on the background of next-genertion of AR inhibitors.
Interventions
- Drug Docetaxel
This is Triple drug regimen for mHSPC - Drug Rezvilutamide
This is doubling drug regimen for mHSPC
Primary outcome measures
- rPFS [Time frame: 36 months]
Secondary outcome measures (2)
- prostate-specific antigen (PSA) response rate [Time frame: 36 months]
- time to castration-resistant prostate cancer (CRPC) [Time frame: 36 months]
Eligibility criteria
Inclusion criteria
- Males aged ≥40 years and ≤80 years.
- Histologically or cytologically confirmed prostate adenocarcinoma.
- Metastatic disease.
- Eligible for ADT and Docetaxel.
- Started or not started first-generation androgen deprivation therapy (ADT), but not exceeding 12 weeks before randomization.
- ECOG score of 0 or 1.
- Laboratory tests meet the following requirements:
- Hematology: neutrophils ≥1.5×10\^9/L, platelets ≥100×10\^9/L, hemoglobin ≥9g/dL.
- Renal function: serum creatinine ≤1.5× upper limit of normal (ULN).
- Liver function: aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5× ULN, total bilirubin (TBIL) ≤1.5× ULN.
- Coagulation function: international normalized ratio (INR) <1.5.
- Study subjects: Patients with mHSPC have a confirmed pathology of prostate adenocarcinoma with high tumor burden, which is defined by having at least one of the following conditions:
1\) Bone scan showing ≥4 bone metastatic lesions (with at least one site outside the pelvis or spine).
2\) CT/MRI revealing visceral metastatic lesions (excluding lymph nodes).
Exclusion criteria
Patients who meet any of the following criteria are not eligible to participate in this study:
- Prior use of LHRH agonists/antagonists; second-generation androgen receptor (AR) inhibitors such as enzalutamide, ARN-509, darolutamide (ODM-201), or other investigational AR inhibitors; CYP17 enzyme inhibitors such as abiraterone acetate or oral ketoconazole for anti-tumor treatment of prostate cancer; chemotherapy or immunotherapy for prostate cancer prior to randomization.
- Received radiation therapy/radiopharmaceutical treatment within 2 weeks before randomization.
- Any of the following conditions within 6 months before randomization: stroke, myocardial infarction, severe/unstable angina pectoris, coronary artery/peripheral artery bypass surgery, congestive heart failure (New York Heart Association class III or IV).
- Previous malignancy, except adequately treated basal cell carcinoma or squamous cell carcinoma of the skin or superficial bladder cancer not invading the deeper muscle layer (i.e., pTis, pTa, and pT1) and any other cancer in complete remission for at least 5 years before randomization.
- Gastrointestinal diseases or procedures that are expected to significantly interfere with the absorption of study treatment.
- Inability to take oral medication.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
China · 1 center
- Urology dpt, First Affiliated Hospital of Nanjing Medical University — Nanjing
Identifiers
NCT: NCT05983783 · 2023-SR-376