Use of Shockwave M5+/L6 IVL Catheter (Intravascular Lithotripsy) in Hostile and Calcified Iliac Access
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Aortic Diseases, Aorto-Iliac Atherosclerosis, Peripheral Arterial Disease. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Italy
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
No-profit, Pilot, Observational, Multicentric, Prospective Study on the Use of Shockwave M5+/L6 IVL Catheter (Intravascular Lithotripsy) in Hostile and Calcified Iliac Access to Facilitate Aortic Endovascular Repair. SHOCK-ACCESS STUDY.
Overview
The study will evaluate, in a controlled setting, the efficacy and safety of the intravascular lithotripsy using Shockwave™ M5+/L6 Peripheral Intravascular Lithotripsy Catheter to facilitate delivery of aortic large-bore devices in iliac calcified access.
Detailed description
This study is designed as no-profit, pilot, observational, multicentric, prospective study.
All eligible subjects for undergoing intervention with Shockwave™ M5+/L6 Peripheral Intravascular Lithotripsy Catheter (IVL) at sites participating in the study will be considered for enrolment and will be asked to give consent prior to participating.
Subjects will be considered enrolled in the study at the time written informed consent is given to the use of their personal data. Once patients are enrolled, their demographics, medical history, disease-relevant conditions, treatment details and outcomes will be collected for up to 12 months from the procedure.
The study will collect information about the medical care patients receive during their planned procedure. No additional testing or procedures will be done.
The procedure with Shockwave™ M5+/L6 Peripheral Intravascular Lithotripsy Catheter (IVL) will be performed as per the current instructions for use.
After discharge all patients will attend clinic visits at 30 days (±14 days), 6 months (±30 days),12 months (±30 days).
Primary outcome measures
- Minimum Lumen Diameter (MLD) Gain [Time frame: Baseline, Day 1]
Secondary outcome measures (12)
- Technical success of Shockwave™ M5+ IVL [Time frame: Day 1]
- Composite of Freedom from iliac complications [Time frame: Day 1, 1 Month]
- Freedom from vessel flow-limiting dissections [Time frame: Day 1, 1 Month]
- Freedom from vessel distal embolization [Time frame: Day 1, 1 Month]
- Freedom from vessel trauma [Time frame: Day 1, 1 Month]
- Freedom from vessel rupture [Time frame: Day 1, 1 Month]
- Freedom from bailout manoeuvres [Time frame: Day 1]
- Freedom from iliac secondary procedures [Time frame: Day 1]
- Freedom from access-site adjunctive/secondary procedures; [Time frame: Day 1]
- Primary patency of the target lesion for each iliac axis treated with IVL [Time frame: 1 month, 6 months, 12 months]
- Freedom from SAE [Time frame: Day 1, 1 month]
- All-cause mortality [Time frame: 1 month, 6 months, 12 moths]
Eligibility criteria
Inclusion criteria
- Age ≥18 years old;
- Patient (or their legal representative) understands the nature of the procedure and provides written informed consent, prior to enrolment in the study;
- Patient presenting with aortic disease indicated for endovascular treatment considered unfeasible based on severely calcified iliac access and outer diameter of the "ideal" aortic endograft at onset of the procedure (considering the main body and/or contralateral limb in case of iliac distal landing zone);
- Patients presenting a ratio > 0.2 between outer diameter of the aortic stent graft delivery system (OD-SG) and minimum lumen diameter (MLD); decision concerning SG will be taken balancing the lower profile on the market and the better graft fit for patient's anatomy;
- Patients presenting calcium grade 3 or 4 accordingly to 360° coronary classification (grade 1 = 0-90°, grade 2 = 90°-180°; grade 3 = 180°-270°; grade 4 = 270°-360°);
- Patients presenting a lesion length > 20 mm, intended as the sum of all calcified iliac lesions between two endpoints, from the aortic bifurcation up to the proximal common femoral artery (CFA);
- Patients eligible for treatment with Shockwave M5+ IVL device;
- Patients presenting with aortic disease indicated for endovascular treatment associated or not to aorto-iliac occlusive disease (Rutherford classification score II - VI for chronic limb ischemia);
- Patients compliant with the conduct of follow-up visits according to the timelines specified in the protocol.
Exclusion criteria
- Bilateral Iliac Occlusion;
- Urgent setting with presence of iliac thrombus (acute limb ischemia);
- Any patient considered to be hemodynamically unstable at procedure onset;
- Patients refusing treatment;
- Patients for whom antiplatelet therapy, anticoagulants or thrombolytic drugs are contraindicated;
- Patients with a history of prior life-threatening contrast medium reaction;
- Life expectancy of less than twelve months.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Italy · 6 centers
- Azienda Ospedaliero Universitaria delle Marche — Ancona
- Sant'Orsola Hospital — Bologna
- Fondazione PTV - Policlinico Tor Vergata — Rome
- Ospedale San Giovanni di Dio — Florence
- Ospedale Santa Maria della Misericordia di Perugia — Perugia
- Azienda Ospedaliero-Universitaria di Padova — Padova
Identifiers
NCT: NCT05880641 · IVL 022022