Carotid Plaque Imaging Project (CPIP)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Observational study.
- Who it may be relevant to
- Registry conditions: Atherosclerosis, Atherosclerotic Plaque. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Sweden
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Carotid Plaque Imaging Project (Identification of Vulnerable Atherosclerotic Plaques With Imaging and Biological Markers)
Overview
The rupture or erosion of an atherosclerotic plaque with thrombosis or embolization often underlie heart attacks and strokes. The early identification of patients with atherosclerotic plaques prone to rupture or erosions, vulnerable plaques (VP), and their treatment before the occurrence of events is, therefore, one of the greatest cardiovascular challenges today. Possible approaches for early detection of VP include imaging techniques allowing visualization of plaque structure, circulating biomarkers and better understanding of the pathophysiologic mechanisms of the disease. In the carotid plaque imaging project the investigators study human atherosclerotic plaques (that are removed by endarterectomy) to disclose their underlying structure and mechanisms, finding possible novel therapeutic targets or markers for VP. The investigators also study plaque structure with imaging methods and try to develop new ways to detect VP using circulating or imaging markers.
Interventions
- Other Observational study
Primary outcome measures
- Number of participants suffering post-operative cardiovascular events (by 2025) [Time frame: Follow up assessment year 2025 (recording of events occurring since 2023)]
- Number of participants suffering post-operative cardiovascular events (by 2027) [Time frame: Follow up assessment year 2027 (recording of events occurring since 2025)]
- Number of participants suffering post-operative cardiovascular events (by 2029) [Time frame: Follow up assessment year 2029 (recording of events occurring since 2027)]
Eligibility criteria
Inclusion criteria
- Patients older than 18 years old, male or female that are eligible for carotid endarterectomy due to atherosclerosis and that can provide informed consent.
Exclusion criteria
- Patients younger than 18 years old that cannot provide informed consent; pregnant.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Sweden · 1 center
- Skåne University Hospital (SUS) — Malmö
Identifiers
NCT: NCT05821894 · CPIP