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Recruiting NCT05793034

Predictive Factors for Survival in Aggressive Meningiomas

No phase Interventional Meningioma Meningioma Atypical Anaplastic Meningioma

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Biological biomarker assessment.
Who it may be relevant to
Registry conditions: Meningioma, Meningioma Atypical, Anaplastic Meningioma. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Italy
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Analysis of Predictive Factors for Overall and Progression-free Survival After Neurosurgery for Atypical or Anaplastic Meningioma

Overview

The investigators plan to collect clinical and molecular data, including ICH, PCR, NGS and methylome, from patients operated on for grade 2 or grade 3 meningioma. The purpose of the study is to identify reliable and easy-to-assess predictive factors for recurrence and survival after surgery.

Interventions

  • Diagnostic test Biological biomarker assessment
    IHC, PCR, NGS, methylome

Primary outcome measures

  • Recurrence-free survival (RFS) [Time frame: 5 years on average]
Secondary outcome measures (1)
  • Overall survival (OS) [Time frame: 5 years on average]

Eligibility criteria

Inclusion criteria

  • Patient operated for atypical (grade 2) meningioma; or
  • Patient operated for anaplastic (grade 3) meningioma;
  • Timeframe for surgery, 1999-2019

Exclusion criteria

1\) Patient lost at follow-up

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
N/A
Model
Single group
Masking
Open label
Primary purpose
Diagnostic

Study locations

Italy · 1 center
  • Fondazione Policlinico Universitario A. Gemelli IRCCS — Rome

Identifiers

NCT: NCT05793034 · 3459

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗