Hyperpolarized 129Xe MRI Lung Health Cohort
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Hyperpolarized Xe129.
- Who it may be relevant to
- Registry conditions: Healthy. Basic parameters: 25 years — 35 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Hyperpolarized 129Xe MRI to Identify Structural Determinants of Low Lung Function and Respiratory Symptoms in Young Adults From the Lung Health Cohort
Overview
A subset of young adults participating in the American Lung Association (ALA) Lung Health Cohort (LHC) will be imaged using Hyperpolarized 129Xe MRI to assess lung structure and function. Images will be used to improve the understanding of lung health and early lung abnormalities that may lead to chronic lung disease.
Interventions
- Drug Hyperpolarized Xe129
Inhaled hyperpolarized 129Xe used as a signal agent for MRI of the lungs.
Primary outcome measures
- Xe-MRI Apparent Diffusion Coefficient [Time frame: At baseline imaging timepoint]
Eligibility criteria
Inclusion criteria
- Is enrolled in the American Lung Association Lung Health Cohort Study.
- Has completed CT imaging for the LHC study within 2 years of the scheduled Xe-MRI date.
Exclusion criteria
- Pacemaker, internal defibrillator or other implanted electronic devices or any standard MRI contraindications (e.g., claustrophobia, > 140 cm shoulder circumference, dependent on weight distribution).
- Is pregnant or breastfeeding
- Oxygen saturation (SpO2) <88% on room air or with supplemental oxygen.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Cohort
Study locations
United States · 6 centers
- University of Illinois-Chicago — Chicago
- University of Iowa — Iowa City
- University of Kansas Medical Center — Kansas City
- Duke University — Durham
- Baylor College of Medicine — Houston
- MD Anderson Cancer Center — Houston
Identifiers
NCT: NCT05766384 · STUDY00160099