Feedback Loop Between Intracranial Atherosclerosis and Cerebral Small Vessel Disease
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Magnetic resonance imaging.
- Who it may be relevant to
- Registry conditions: ICAS - Intracranial Atherosclerosis, Cerebral Small Vessel Diseases. Basic parameters: from 30 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The present study aims at verifying the mutual effects between intracranial large artery atherosclerosis and cerebral small vessel disease on disease progression and prognosis by magnetic resonance imaging, and providing biomarkers for the early prevention and treatment of cerebrovascular disease.
Detailed description
Cerebrovascular disease is the most common cause of death worldwide. There is a close link in structure and function between the intracranial large arteries and cerebral small vessels. Moreover, growing evidences have demonstrated that large artery atherosclerosis often coexists with small vessel disease, which may deteriorate the clinical outcomes of stroke and dementia. The mutual feedback mechanism between them is not fully understood. The present study focuses on the mechanism of mutual feedback between large artery atherosclerosis and cerebral small vessel disease by using magnetic resonance imaging. The study may provide biomarkers for the early prevention and treatment of cerebrovascular disease.
Interventions
- Diagnostic test Magnetic resonance imaging
Imaging diagnostics mainly based on Magnetic resonance imaging.
Primary outcome measures
- Progression in total cerebral small vessel disease burden [Time frame: 1-3 YEARS]
- Frequency of stroke recurrence [Time frame: 1-3 YEARS]
Secondary outcome measures (1)
- Frequency of stroke of asymptomatic participants [Time frame: 1-3 YEARS]
Eligibility criteria
Inclusion criteria
- Age ≥ 18 years
- At least one intracranial artery ≥ 50% atherosclerotic stenosis
- Modified Rankin Scale < 2
- Mini-mental State Examination > 24
Exclusion criteria
- Concurrent ipsilateral extracranial artery ≥ 50% stenosis
- Pregnant women
- Contraindications to magnetic resonance examination (patients with pacemakers, nerve stimulators, artificial metal heart valves and other metal foreign bodies)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Chinese PLA General Hospital — Beijing
Identifiers
NCT: NCT05677607 · 301Brainmax