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Recruiting NCT05672784

Genicular Nerve Block Versus Its Combination With Infiltration Between Popliteal Artery and Capsule of Posterior Knee

No phase Interventional Postoperative Pain

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: GNB plus standard analgesia, GNB plus IPACK block plus standard analgesia, standard analgesia (paracetamol and meloxicam).
Who it may be relevant to
Registry conditions: Postoperative Pain. Basic parameters: 21 years — 60 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Egypt
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Genicular Nerve Block Versus Its Combination With Infiltration Between Popliteal Artery and Capsule of Posterior Knee for Enhanced Recovery After Total Knee Arthroplasty

Overview

Comparison of the analgesic and physical recovery effect of genicular nerve block (GNB) alone and (GNB + infiltration between popliteal artery and posterior capsule of the knee (IPACK) in patients undergoing total knee replacement

Detailed description

Comparison of preemptive analgesia of (GNB) with (GNB+ IPACK) on postoperative pain control and recovery of knee physical activity in patient undergoing total knee replacement.

Interventions

  • Procedure GNB plus standard analgesia
    When patients are in supine position with a pillow under the popliteal fossa, we will target points next to superior medial, superior lateral, and inferior medial genicular arteries to block the superior medial, superior lateral, and inferior medial branches of genicular nerve. For identification, we will use color Doppler near the periosteal areas (the junctions of the epicondyle with the shafts of the femur and tibia, accordingly). using a 12 MHz linear transducer (XarioTM SSA-660A, Toshiba Me
  • Procedure GNB plus IPACK block plus standard analgesia
    IPACK block will be done when the patients in supine position with the knee flexed in 45 degree. using a low frequency transducer at a depth of 3.5-4 cm positioned transversely, 2-3 cm above the patella and over the medial aspect of the knee, we will identify the distal part of the shaft of the femur and the popliteal artery with sliding the transducer proximally and distally (If the two femoral condyles appear first, proximal sliding of the probe, so the humps of the femoral condyles will disap
  • Drug standard analgesia (paracetamol and meloxicam)
    (paracetamol 1 gm 3 times a daily and meloxicam (15 mg) once aday.

Primary outcome measures

  • 2 hours visual analogue scale [Time frame: at 2 hour postoperative.]
  • 4 hours visual analogue score [Time frame: at 4 hours postoperative]
  • 6 hours visual analogue score [Time frame: at 6 hours postoperative]
  • 8 hours visual analogue score [Time frame: at 8 hours postopertaive]
  • 12 hours visual analogue score [Time frame: at 12 hours postoperative]
  • 18 hours visual analogue score [Time frame: at 18 hours postoperative]
  • 24 hours visual analogue score [Time frame: at 24 hours postoperative]
Secondary outcome measures (7)
  • • Time of performance of block [Time frame: from putting of U.S probe till the end of block procedure]
  • • Total morphine consumption [Time frame: at 24 hours post-operatively]
  • •incidence of Anticipated side effect [Time frame: at 24,48 hours postoperative]
  • degree of maximum active flexion and extension of the knee [Time frame: at 24 hours post operative]
  • walk test [Time frame: at 24 hours post operative]
  • holding quadriceps muscle [Time frame: at 24 hours post operative]
  • time up and go (TUG) [Time frame: at 24 hours post operative]

Eligibility criteria

Inclusion criteria

  • Adult patients aged between 21 to 60 years
  • undergoing primary unilateral elective total knee arthroplasty under spinal anesthesia
  • Having informed consents
  • patients with physical status ASA I \& II
  • both genders
  • body mass index less than 40 kg/m2.

Exclusion criteria

  • patients with Peripheral vascular disease
  • patients with history of allergy to local anesthesia or opioid analgesia,
  • those on anti-platelet, anticoagulant or B blocker drugs
  • Patients with acute decompensated heart failure
  • Patients with hypertension
  • Patients with heart block
  • Patients with coronary disease
  • Patients with bronchial asthma
  • Patients with bleeding disorders
  • Patients with compromised renal or hepatic function
  • pregnant female.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Single blind
Primary purpose
Supportive care

Study locations

Egypt · 1 center
  • Heba M Fathi — Zagazig

Publications

  • Fathi HM, Fahmy AM, Shaker MA, Kamel AAF. Comparison of genicular nerve block and its combination with IPACK block for analgesia and recovery after total knee arthroplasty: a randomized trial. BMC Anesthesiol. 2025 Nov 29;25(1):601. doi: 10.1186/s12871-025-03408-0. PMID 41318369

Identifiers

NCT: NCT05672784 · 9577/19-9-2022

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗