Neural Mechanisms of Obsessive-compulsive Disorder (OCD) Treatment Failure
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Obsessive-Compulsive Disorder. Basic parameters: 18 years — 55 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United Kingdom
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Cognitive and Neural Networks in Psychiatry (CNNP): Neural Mechanisms of Obsessive-compulsive Disorder (OCD) Treatment Failure (ERP in Silico)
Overview
The aim of this study is to understand why patients with obsessive-compulsive disorder (OCD) fail in therapy. To understand the neural mechanisms involved in exposure therapy that support success and clinical improvement in order to improve therapy outcomes for OCD patients.
Detailed description
A course of therapy is recommended for individuals with obsessive-compulsive disorder (OCD). It is usually a type of cognitive behavioural therapy (CBT) with exposure and response prevention (ERP).
In this study the investigators assess patients pre-therapy and post-therapy evaluating symptom severity (measured by the Y-BOCS) and decision-making (measured by online questionnaires and computer-based behavioural tasks).
To examine how decisions are formed in patients undergoing OCD CBT, how behaviour changes after a non-pharmacological therapy module and how it is associated to the alleviation of OCD symptoms.
The study, which will recruit 90 patients, is based at University College London - Wellcome Centre for Human Neuroimaging. This study is a part of the Cognitive and Neural Networks in Psychiatry (CNNP) study.
Primary outcome measures
- Yale-Brown obsessive compulsive scale (Y-BOCS) [Time frame: 3 - 9 months]
- Decision making and learning tasks [Time frame: 3 - 9 months]
Secondary outcome measures (10)
- Patient EX/RP Adherence Scale (PEAS) [Time frame: 3 - 9 months]
- Short form of Obsessive Beliefs Questionnaire (OBQ) [Time frame: 3 - 9 months]
- Brief Experiential Avoidance Questionnaire (BEAQ) [Time frame: 3 - 9 months]
- International Cognitive Ability Resource (ICAR16) [Time frame: 3 - 9 months]
- Worry Domains Questionnaire - Short Form (WDQ-SF) [Time frame: 3 - 9 months]
- The World Health Organization Quality of Life Brief Version (WHOQOL-BREF) [Time frame: 3 - 9 months]
- Sheehan Disability Scale (SDS) [Time frame: 3 - 9 months]
- State-Trait Anxiety Inventory (STAI) [Time frame: 3 - 9 months]
- Zung Self-Rating Depression Scale (SDS) [Time frame: 3 - 9 months]
- Anxiety Sensitivity Index (ASI-3) [Time frame: 3 - 9 months]
Eligibility criteria
Inclusion criteria
- Diagnosis of obsessive-compulsive disorder (OCD)
- Fluent in written and spoken English
- Normal/corrected to normal vision
- Expecting to start OCD therapy
Exclusion criteria
- Autism spectrum disorder, psychosis, schizophrenia, addiction, substance abuse, bipolar, hoarding, or Tourette disorder
- Hearing conditions: tinnitus, ear inflammation, hearing sensitivity, hearing loss, requires hearing aids
- Colour blindness
- Severe learning disabilities
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
United Kingdom · 1 center
- Max Planck UCL Centre for Computational Psychiatry and Ageing Research — London
Identifiers
NCT: NCT05520398 · 15/0541