EyeConic: Qualification for Cone-Optogenetics
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Optical coherence tomography (OCT).
- Who it may be relevant to
- Registry conditions: Retinal Dystrophies. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States, China, Germany, Hungary, Italy +2
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Qualification for Cone-Optogenetics (EyeConic)
Overview
This study aims to prepare for the first-in-human clinical trial of cone optogenetics vision restoration. As a first step, this worldwide multicenter ocular imaging study (EyeConic Study) is performed to identify eligible patients.
Detailed description
In a subset of patients with inherited retinal dystrophies (IRDs), cones lose their light-sensitive outer segments but remain alive in a dormant stage. This creates an opportunity to resensitize them through targeted optogenetic tools. However, the true proportion of low vision patients harboring dormant, non-functional cones, is currently unknown. The worldwide multicenter retrospective study (EyeConic) aims to estimate the proportion of low vision patients with remaining cone cell bodies for the first time.
Interventions
- Diagnostic test Optical coherence tomography (OCT)
Data of macular optical coherence tomography (OCT)
Primary outcome measures
- OCT - Central retinal volume [Time frame: Baseline (about 10 minutes)]
Eligibility criteria
Inclusion Criteria (patients):
- Diagnosis of generalized IRD
- Low vision as defined as visual acuity worse or equal to 0.05 (or 20/400) in the study eye
- Availability of macular optical coherence tomography (OCT)
Inclusion Criteria (controls):
- Normal ophthalmic findings
- Availability of macular optical coherence tomography (OCT)
Exclusion Criteria (all):
- Other eye diseases with a significant effect on vision or retinal structure
- Extraocular disease affecting retinal structure such as neurodegenerative diseases
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
United States · 3 centers
- University of California San Francisco, Department of Ophthalmology — San Francisco
- Bascom Palmer Eye Institute — Miami
- University of Pittsburgh, Department of Ophthalmology — Pittsburgh
China · 1 center
- Beijing Institute of Ophthalmology — Beijing
Germany · 1 center
- Universitätsklinikum Tübingen Augenklinik — Tübingen
Hungary · 1 center
- Semmelweis University, Department of Ophthalmology — Budapest
Italy · 1 center
- Oculista Ospedale Parma — Parma
Switzerland · 1 center
- University Hospital Basel, Eye Clinic — Basel
United Kingdom · 1 center
- Moorfields Eye Hospital — London
Identifiers
NCT: NCT05294978 · IOB_EyeConic_2021