Cognitive Testing Online in Parkinson's Disease
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Neurocognitive testing.
- Who it may be relevant to
- Registry conditions: Parkinson Disease. Basic parameters: 45 years — 90 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Canada
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Deep Cognitive Endophenotyping of Parkinson's Disease: A Platform Development and Pilot Study
Overview
This is a feasibility and pilot study. Though large-scale online neurocognitive testing is increasingly being done in psychiatry, there are no such efforts in Parkinson's research. Thus a large part of this pilot study will be to demonstrate feasibility and reliability, and use this experience to develop a feasible protocol for ongoing research. The specific short-term objectives are: 1. To establish the feasibility of performing large-scale deep cognitive phenotyping using online cognitive testing. 2. To demonstrate that online neurocognitive testing is valid and reliable in a smaller sample of locally recruited participants tested both in-lab and online.
Interventions
- Other Neurocognitive testing
We are assessing several cognitive domains and have made minor adaptations (reducing the total number of trials or lengthening response windows) to several standard neuropsychology tests including measures of executive function, working memory, visuospatial function, declarative memory, reward processing, response inhibition. Overall, the tests we use follow a standard set-up: participants are shown stimuli on the screen and are asked to provide a response using either a keyboard or a mouse, ba
Primary outcome measures
- Completion rate of cognitive test set (feasibility) [Time frame: Measured once, as this is a cross-sectional study (time to complete cognitive tests is estimated to be 1.5 hours)]
Secondary outcome measures (5)
- Reliability of web-based vs in-person working memory testing (n-back test) [Time frame: Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart]
- Reliability of web-based vs in-person executive function testing (Stroop test performance) [Time frame: Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart]
- Reliability of web-based vs in-person visuospatial function testing (Trail making test performance) [Time frame: Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart]
- Reliability of web-based vs in-person declarative memory testing (recognition memory) [Time frame: Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart]
- Reliability of web-based vs in-person reward processing testing [Time frame: Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart]
Eligibility criteria
Inclusion criteria
- diagnosis of Parkinson's disease by neurologist or healthy individual with no diagnosis of any neurological illness
Exclusion criteria
- Psychotic spectrum disorders, active uncontrolled depression, advanced dementia (i.e. needing assistance with daily activities such as dressing or bathing), major stroke, major head injury, epilepsy requiring anti-seizure medications
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
Canada · 1 center
- McGill University Health Centre — Montreal
Identifiers
NCT: NCT05025254 · 2020-6045