Cognitive Testing Online in Parkinson's Disease

Официальное название

Deep Cognitive Endophenotyping of Parkinson's Disease: A Platform Development and Pilot Study

Обзор

This is a feasibility and pilot study. Though large-scale online neurocognitive testing is increasingly being done in psychiatry, there are no such efforts in Parkinson's research. Thus a large part of this pilot study will be to demonstrate feasibility and reliability, and use this experience to develop a feasible protocol for ongoing research. The specific short-term objectives are: 1. To establish the feasibility of performing large-scale deep cognitive phenotyping using online cognitive testing. 2. To demonstrate that online neurocognitive testing is valid and reliable in a smaller sample of locally recruited participants tested both in-lab and online.

Вмешательства

• Другое Neurocognitive testing
  We are assessing several cognitive domains and have made minor adaptations (reducing the total number of trials or lengthening response windows) to several standard neuropsychology tests including measures of executive function, working memory, visuospatial function, declarative memory, reward processing, response inhibition. Overall, the tests we use follow a standard set-up: participants are shown stimuli on the screen and are asked to provide a response using either a keyboard or a mouse, ba

Первичные конечные точки

• Completion rate of cognitive test set (feasibility) [Срок оценки: Measured once, as this is a cross-sectional study (time to complete cognitive tests is estimated to be 1.5 hours)]

Вторичные конечные точки (5)

• Reliability of web-based vs in-person working memory testing (n-back test) [Срок оценки: Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart]
• Reliability of web-based vs in-person executive function testing (Stroop test performance) [Срок оценки: Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart]
• Reliability of web-based vs in-person visuospatial function testing (Trail making test performance) [Срок оценки: Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart]
• Reliability of web-based vs in-person declarative memory testing (recognition memory) [Срок оценки: Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart]
• Reliability of web-based vs in-person reward processing testing [Срок оценки: Web-based and in-person testing will occur at two separate time points, at least 1 month apart and no more than 3 months apart]

Критерии участия

Критерии включения

• diagnosis of Parkinson's disease by neurologist or healthy individual with no diagnosis of any neurological illness

Критерии исключения

• Psychotic spectrum disorders, active uncontrolled depression, advanced dementia (i.e. needing assistance with daily activities such as dressing or bathing), major stroke, major head injury, epilepsy requiring anti-seizure medications

Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.

Здоровые добровольцы: Да

Дизайн исследования

Модель наблюдения

Когортное

Центры проведения

Канада · 1 центр

• McGill University Health Centre — Montreal

Идентификаторы

NCT: NCT05025254 · 2020-6045

Первоисточники (государственные реестры)

• ClinicalTrials.gov (NIH, США)

Открыть это исследование на ClinicalTrials.gov ↗