Discovery of Biomarkers for Intrinsic Radiation Sensitivity in Cancer Patients
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Nasopharyngeal Cancer, Prostate Cancer, Other Cancer. Basic parameters: 21 years — 99 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Singapore
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Patients with cancers that are sensitive to radiotherapy treatment and/or patients who have experienced severe acute/ late side effects to radiotherapy will be recruited to the study. Blood and/or matched tumour-normal tissue pairs will be collected. Blood and/or tissue samples will be processed and studied for genetic and biochemical markers that have potential to be used for predicting sensitivity to radiation.
Primary outcome measures
- To identify genes or molecular pathways that are associated with radiation sensitivity in blood and tissue samples [Time frame: Blood is taken at informed consent; tissue is from archived sample]
- Change in immune profile of blood and tissue after radiation [Time frame: Blood is taken at informed consent; tissue is from archived sample]
- To identify proteins that are associated with radiation sensitivity in tissue samples [Time frame: Tissue is from archived sample]
- To identify RNA expression pathways that are associated with radiation sensitivity in blood and tissue samples [Time frame: Blood is taken at informed consent; tissue is from archived sample]
Eligibility criteria
Inclusion criteria
- Patients with severe side effects from radiotherapy
- Patients with a type of cancer that is associated with sensitivity to radiotherapy
Exclusion criteria
- Age of patient must be between 21 (inclusive) and 99 (exclusive)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Singapore · 1 center
- National Cancer Center Singapore — Singapore
Identifiers
NCT: NCT04340024 · DISCLOSE