Protein Needs Study
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Phenylalanine intake.
- Who it may be relevant to
- Registry conditions: Colorectal Cancer, Breast Cancer. Basic parameters: 45 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Canada
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Innovative Approaches to the Lack of Evidence-based Dietary Protein Requirements for Patients With Cancer
Overview
Severe muscle loss in patients with cancer has been associated with increased physical disability, extended hospitalization, infectious and noninfectious complications, increased risk of severe toxicity during cancer treatment, poor quality of life and shortened survival. Adequate protein is key to sustain muscle mass and overall health. However, current nutritional recommendations are not specific or evidence-based. The aim of this project is to determine the protein needs of patients with colorectal or breast cancer. Protein needs will be determined using a novel, non-invasive approach. Our results will inform nutritional recommendations and guidelines with the ultimate goal of improving outcomes for people with cancer.
Interventions
- Dietary supplement Phenylalanine intake
Oral consumption of eight hourly experimental meals- Includes 4 tracer-free experimental meals containing a mixture of free amino acids, calories from a flavored liquid and protein-free cookies and 4 labeled amino acid experimental meals.
Primary outcome measures
- 13C Phenylalanine Oxidation [Time frame: 8.5 hours]
Eligibility criteria
Inclusion criteria
- Outpatients age 45-80 years;
- Patients attending the new patient clinic at the Cross Cancer Institute with a diagnosis of colorectal cancer or breast cancer (stages II to III);
- Able to complete baseline visits within approximately 4 weeks of starting chemotherapy OR after a minimum of 4 weeks post-surgery if not undergoing chemotherapy;
- Ambulatory.
Exclusion criteria
- Premenopausal women due to impact on protein requirements;
- Received anti-cancer hormone treatment or immunotherapy in the 4 weeks before first baseline visit;
- Renal impairment based on a creatinine clearance for estimated glomerular filtration rate (eGFR) of <60 mL/min
- Abnormal glucose metabolism based on a fasting glucose level >6mmol/L and an HbA1c >5.7% or as reviewed by study team;
- Comorbidities or medications that would interfere with the participants ability to follow the study protocol or the quality of the data(e.g. diabetes, class III obesity, hormone therapy, another active cancer diagnosis);
- Unable/unwilling to provide urine, breath and blood samples (e.g. oxygen tank, catheter, etc.);
- Unable to eat the meals provided (i.e. receiving parenteral or enteral nutrition, severe allergies);
- Substance dependent (e.g. alcohol, cigarettes, illicit drugs) and unable to follow study protocols.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
Canada · 1 center
- University of Alberta — Edmonton
Identifiers
NCT: NCT04144907 · HREBA.CC-19-0354