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Enrolling by invitation NCT03927638

Differences in Sitting Versus Standing on Metabolic and Cardiovascular Measurements

— Observational Overweight and Obesity

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: sit/stand.
Who it may be relevant to
Registry conditions: Overweight and Obesity. Basic parameters: 18 years — 50 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Overview

This investigations examined the effect that posture has on metabolic and cardiovascular measurements. Further, it will explore the potential for body weight status or physical activity to influence these relationships. All subjects will complete a seated condition and a standing condition in a counterbalanced manner.

Detailed description

The purpose of the present study was to evaluate both metabolic and cardiovascular responses to acute bouts of computer work while sitting and standing. Cardiovascular measurements were made using continuous non-invasive blood pressure monitoring and metabolic measurements were made using indirect calorimetry. Subjects will be grouped and analyzed based upon the weight status of the subject. All subjects will complete a seated condition and a standing condition in a counterbalanced manner. Investigators hypothesize that metabolic and cardiovascular responses will be elevated in the standing condition compared to sitting.

Interventions

  • Behavioral sit/stand
    Subjects will be asked to both sit and stand during a single trial.

Primary outcome measures

  • Heart Rate [Time frame: Approximately 15 minutes in each condition (sitting and standing)]
  • Systolic Blood Pressure (SBP) [Time frame: Approximately 15 minutes in each condition (sitting and standing)]
  • Diastolic Blood Pressure (DBP) [Time frame: Approximately 15 minutes in each condition (sitting and standing)]
  • Oxygen Consumption [Time frame: Approximately 15 minutes in each condition (sitting and standing)]
  • Carbon Dioxide Production [Time frame: Approximately 15 minutes in each condition (sitting and standing)]
  • Ventilation [Time frame: Approximately 15 minutes in each condition (sitting and standing)]
  • Respiratory Exchange Ration (RER) [Time frame: Approximately 15 minutes in each condition (sitting and standing)]
Secondary outcome measures (8)
  • Height [Time frame: 1 minute]
  • Weight [Time frame: 1 minute]
  • Body Mass Index (BMI) [Time frame: 1 minute]
  • Body Composition [Time frame: Approximately 15 minutes]
  • Total Peripheral Resistance (TPR) [Time frame: Approximately 15 minutes in each condition (sitting and standing)]
  • Stroke Volume [Time frame: Approximately 15 minutes in each condition (sitting and standing)]
  • Cardiac Output (Q) [Time frame: Approximately 15 minutes in each condition (sitting and standing)]
  • Muscle Oxygen Saturation [Time frame: Approximately 15 minutes in each condition (sitting and standing)]

Eligibility criteria

Inclusion criteria

  • healthy adult

Exclusion criteria

  • Have a history of cancer, cardiac issues, hypertension, pulmonary disease, stroke, neurological or muscular dystrophy, uncontrolled diabetes, or any life threatening chronic conditions.
  • Are currently being treated for infectious mononucleosis, hepatitis, pneumonia, or other infectious diseases.
  • Are unable or unwilling to stand in one position continuously for 15-20 minutes at a time.
  • Use nicotine products, or non-contraceptive hormonal therapy (birth control is okay).
  • Are pregnant or trying to become pregnant.
  • Are not between 18 and 50 years of age.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

United States · 1 center
  • Montclair State University — Montclair

Publications

  • Hosick PA, Willett JM, Matthews EL. Cardiovascular strain and metabolic rate are higher following 15 minutes of standing versus seated computer work. Eur J Prev Cardiol. 2020 Dec;27(19):2131-2133. doi: 10.1177/2047487319867402. Epub 2019 Jul 29. No abstract available. PMID 31357884

Identifiers

NCT: NCT03927638 · 17-18-861

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗