Coexistence of Cerebral and Coronary Atherosclerosis in Acute Ischemic Cerebrovascular Disease Patients Registry
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: observational only- no intervention.
- Who it may be relevant to
- Registry conditions: Coexistence of Cerebral and Coronary Atherosclerosis, Acute Ischemic Cerebrovascular Disease. Basic parameters: 18 years — 85 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Coexistence of Cerebral and Coronary Atherosclerosis in Acute Ischemic Cerebrovascular Disease Patients Registry (CoCCA) is a single-center observational registry of patients hospitalized for acute ischemic cerebrovascular disease (AICVD) with atherosclerotic changes in both cerebral and coronary arteries. This registry aims to establish quantified risk stratification and prognostic models, as well as suggest effective diagnostic and therapeutic strategies.
Detailed description
Atherosclerosis has exerted huge global burden as the common pathological process underlying ischemic heart disease and cerebrovascular disease. A substantial portion of acute ischemic cerebrovascular disease (AICVD) patients have both cerebral and coronary atherosclerosis, which is an omen of poor outcomes. But there is large evidence gap in these high-risk patients' prognosis-related factors, limiting the improvement of care quality.
Coexistence of Cerebral and Coronary Atherosclerosis in Acute Ischemic Cerebrovascular Disease Patients Registry (CoCCA) is a single-center prospective observational registry of patients hospitalized for AICVD with atherosclerotic changes in both cerebral and coronary arteries.
This registry aims to establish quantified risk stratification and prognostic models, as well as suggest effective diagnostic and therapeutic strategies.
The clinical, imaging and laboratory information will be collected at the baseline. During an estimated 5-year follow-up, the vessel-related diagnostic or monitoring procedures, treatment, functional status and new vascular events will be recorded by web-based patients' self-reports, investigators' regular telephone visits.
Interventions
- Other observational only- no intervention
observational only- no intervention
Primary outcome measures
- Rate of Major Adverse Cardiovascular Events [Time frame: 1 year]
Secondary outcome measures (11)
- Rate of Major Adverse Cardiovascular Events [Time frame: 90 days]
- Functional Outcome [Time frame: 90 days]
- Rate of Ischemic Stroke [Time frame: 1 year]
- Rate of Acute Coronary Syndrome [Time frame: 1 year]
- Rate of Cardiovascular Mortality [Time frame: 1 year]
- Time to First Major Adverse Cardiovascular Event [Time frame: 5 years]
- Time to First Ischemic Stroke [Time frame: 5 years]
- Rate of Major Adverse Cardiovascular Events [Time frame: 5 years]
- Rate of Ischemic Stroke [Time frame: 5 years]
- Rate of Acute Coronary Syndrome [Time frame: 5 years]
- Rate of Cardiovascular Mortality [Time frame: 5 years]
Eligibility criteria
Inclusion criteria
- Diagnosed as ischemic stroke or transient ischemic attack (TIA).
- Less than 30 days after onset of ischemic stroke or TIA symptoms.
- Extracranial or intracranial cerebral atherosclerosis confirmed by vascular ultrasound or CT angiograpgy or MR angiograpgy or digital substraction angiography.
- Coronary atherosclerosis confirmed by CT angiograpgy or MR angiograpgy or digital substraction angiography; or with myocardial ischemia symptoms confirmed using electrocardiogram or echocardiography or cardiac MR; or with a history of percutaneous coronary intervention or coronary artery bypass graft.
Exclusion criteria
- With malignant tumors or poor organ functions or hematologic diseases, whose estimated life expectancy is less than 5 years.
- Patients refuse to participate in the research.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Xuanwu Hospital, Capital Medical University — Beijing
Identifiers
NCT: NCT03788512 · CoCCA