Prospective Cohort Study on Cognition and Cardiovascular Disease of Sedentary Behaviors in Children
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Sedentary Behavior;Cognition;Cardiovascular-related Disease. Basic parameters: 7 years — 12 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The prospective cohort study is set up to address research questions dealing with sedentary lifestyle-related events mainly including cognition and cardiovascular-related disease in children .Participants aged 7-12 years old from five primary schools in Guangzhou,Guangdong province will be recruited and followed up to evaluate the risk factors of cognition and cardiovascular-related disease. Objective measurements combined with questionnaire-data-based information on a wide range of lifestyle factors and cognition were applied in this study.
Detailed description
There are three stages in this project.At first stage,information about socio-demographic, psychological status, physical activity,sleep and diet were collected by a multi-components questionnaire survey.The Strengths and Difficulties Questionnaire(SDQ) and Behavior Rating Inventory of Executive Function(BRIEF) were conducted at the same time. Anthropometric measurement including height, weight, waist and hip circumferences, blood pressure and fat mass were conducted.Besides,blood samples were collected to measure total cholesterol, triglycerides, high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C).
At second stage,participants were classified for 4 subgroups as follows: Low active-high sedentary;low active-low sedentary; high active-high sedentary;high active-low sedentary by different sedentary status and physical activity levels according to the international standard. Later cardiorespiratory fitness was assessed by the 20-m shuttle run test. Accelerometer GT3X+ Actigraph with physical activity log,Combined Raven's test, a series of psychometric paradigms were measured for further studies.
At third stage,we will explore the related neuropsychological mechanism using the technology of event-related potentials (ERPs).
About 1000 participants (7-12 years old) will be prospectively followed up. The associations between sedentary lifestyle and risks for cognition and cardiovascular-related disease will be evaluated.
Primary outcome measures
- Self-reported physical activity and sedentary lifestyle. [Time frame: 2017.01-2026.12]
Secondary outcome measures (10)
- Anthropometric [Time frame: 2017.01-2026.12]
- Biochemical indicator [Time frame: 2017.01-2026.12]
- Cardiorespiratory Fitness(CRF) [Time frame: 2017.01-2026.12]
- Self-reported cognition [Time frame: 2017.01-2026.12]
- Objective measurement of physical activity and sedentary lifestyle. [Time frame: 2017.01-2026.12]
- Corsi block-tapping task [Time frame: 2017.01-2026.12]
- Stroop task [Time frame: 2017.01-2026.12]
- Wisconsin Card Sorting Test(WCST) [Time frame: 2017.01-2026.12]
- Combined Raven's Test [Time frame: 2017.01-2026.12]
- Event-related potentials [Time frame: 2018.09-2026.12]
Eligibility criteria
Inclusion criteria
- 7-12 years old
- Children with normal intelligence measured by Raven Good vision.
- Right hand.
Exclusion criteria
- Children with mental health and behavioral problems in this study were found to have developmental behavior disorders, such as ADHD, ASD.
- There are serious liver and kidney diseases, cardiovascular diseases, hematologic diseases or malignant tumors.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Publications
- Lv Y, Cai L, Zeng X, Gui Z, Lai L, Tan W, Chen Y. Association between weekend catch-up sleep and executive functions in Chinese school-aged children. J Clin Sleep Med. 2020 Aug 15;16(8):1285-1293. doi: 10.5664/jcsm.8494. PMID 32279704
- Lv Y, Cai L, Gui Z, Zeng X, Tan M, Wan N, Lai L, Lu S, Tan W, Chen Y. Effects of physical activity and sedentary behaviour on cardiometabolic risk factors and cognitive function in children: protocol for a cohort study. BMJ Open. 2019 Oct 31;9(10):e030322. doi: 10.1136/bmjopen-2019-030322. PMID 31676650
Identifiers
NCT: NCT03582709 · 8167120522