Prospective Cohort Study on Cognition and Cardiovascular Disease of Sedentary Behaviors in Children
Ориентир для пациента и семьи
Простыми словами
Автоматическая сводка по структурированным данным реестра. Она помогает сориентироваться, но не заменяет официальный протокол или оценку врача.
- Что изучают
- Это наблюдательное исследование: исследуемое лечение участникам по протоколу не назначают.
- Кому может быть актуально
- Состояния в реестре: Sedentary Behavior;Cognition;Cardiovascular-related Disease. Базовые параметры: 7 лет — 12 лет · Все.
- Что важно проверить
- Возраст, диагноз и пол — только базовые ориентиры. Предыдущее лечение, анализы и другие обязательные условия указаны ниже в критериях участия.
- Где проводится
- Список центров уточняется — проверьте первичный протокол.
- Следующий шаг
- Сохраните исследование, покажите его лечащему врачу и уточните актуальный статус у исследовательского центра. Расходы, документы и поездка →
Не всё понятно в терминах? Прочитайте наш гид для пациентов →
Обзор
The prospective cohort study is set up to address research questions dealing with sedentary lifestyle-related events mainly including cognition and cardiovascular-related disease in children .Participants aged 7-12 years old from five primary schools in Guangzhou,Guangdong province will be recruited and followed up to evaluate the risk factors of cognition and cardiovascular-related disease. Objective measurements combined with questionnaire-data-based information on a wide range of lifestyle factors and cognition were applied in this study.
Подробное описание
There are three stages in this project.At first stage,information about socio-demographic, psychological status, physical activity,sleep and diet were collected by a multi-components questionnaire survey.The Strengths and Difficulties Questionnaire(SDQ) and Behavior Rating Inventory of Executive Function(BRIEF) were conducted at the same time. Anthropometric measurement including height, weight, waist and hip circumferences, blood pressure and fat mass were conducted.Besides,blood samples were collected to measure total cholesterol, triglycerides, high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C).
At second stage,participants were classified for 4 subgroups as follows: Low active-high sedentary;low active-low sedentary; high active-high sedentary;high active-low sedentary by different sedentary status and physical activity levels according to the international standard. Later cardiorespiratory fitness was assessed by the 20-m shuttle run test. Accelerometer GT3X+ Actigraph with physical activity log,Combined Raven's test, a series of psychometric paradigms were measured for further studies.
At third stage,we will explore the related neuropsychological mechanism using the technology of event-related potentials (ERPs).
About 1000 participants (7-12 years old) will be prospectively followed up. The associations between sedentary lifestyle and risks for cognition and cardiovascular-related disease will be evaluated.
Первичные конечные точки
- Self-reported physical activity and sedentary lifestyle. [Срок оценки: 2017.01-2026.12]
Вторичные конечные точки (10)
- Anthropometric [Срок оценки: 2017.01-2026.12]
- Biochemical indicator [Срок оценки: 2017.01-2026.12]
- Cardiorespiratory Fitness(CRF) [Срок оценки: 2017.01-2026.12]
- Self-reported cognition [Срок оценки: 2017.01-2026.12]
- Objective measurement of physical activity and sedentary lifestyle. [Срок оценки: 2017.01-2026.12]
- Corsi block-tapping task [Срок оценки: 2017.01-2026.12]
- Stroop task [Срок оценки: 2017.01-2026.12]
- Wisconsin Card Sorting Test(WCST) [Срок оценки: 2017.01-2026.12]
- Combined Raven's Test [Срок оценки: 2017.01-2026.12]
- Event-related potentials [Срок оценки: 2018.09-2026.12]
Критерии участия
Критерии включения
- 7-12 years old
- Children with normal intelligence measured by Raven Good vision.
- Right hand.
Критерии исключения
- Children with mental health and behavioral problems in this study were found to have developmental behavior disorders, such as ADHD, ASD.
- There are serious liver and kidney diseases, cardiovascular diseases, hematologic diseases or malignant tumors.
Критерии приведены из реестра в оригинале (на английском). Окончательную оценку соответствия проводит исследовательский центр.
Дизайн исследования
- Модель наблюдения
- Когортное
Центры проведения
Список центров уточняется — проверьте первичный протокол.
Публикации
- Lv Y, Cai L, Zeng X, Gui Z, Lai L, Tan W, Chen Y. Association between weekend catch-up sleep and executive functions in Chinese school-aged children. J Clin Sleep Med. 2020 Aug 15;16(8):1285-1293. doi: 10.5664/jcsm.8494. PMID 32279704
- Lv Y, Cai L, Gui Z, Zeng X, Tan M, Wan N, Lai L, Lu S, Tan W, Chen Y. Effects of physical activity and sedentary behaviour on cardiometabolic risk factors and cognitive function in children: protocol for a cohort study. BMJ Open. 2019 Oct 31;9(10):e030322. doi: 10.1136/bmjopen-2019-030322. PMID 31676650
Идентификаторы
NCT: NCT03582709 · 8167120522