GI & liver

8,202 trials in this section

Recruiting NCT06458712

Study to Assess Safety, Tolerability and Activity of DSB2455 in Participants With Advanced Malignancies

Phase I Interventional United States, France +3

Advanced Cancers (Breast, Ovarian, mCRPC, Pancreatic Ductal Adenocarcinoma (PDAC), Brain Mets) With Specific Mutations (Homologous Recombination Deficiency)

Not yet recruiting NCT07714291

CPHARM - CRC Study

No phase Interventional Malaysia

Colorectal Cancer

Not yet recruiting NCT07714980

TEAS Timing for Gastrectomy Recovery (TEAS-TIME Trial)

No phase Interventional China

Gastric Cancer (GC) · Stomach Neoplasms

Recruiting NCT07382349

A Study of Electronic Clinical Decision Support Tools for Steatotic Liver Disease

No phase Interventional United States

MASLD

Recruiting NCT07051863

Prospective Cohort and Biobank of Patients With Nonalcoholic Fatty Liver Disease

— Observational Switzerland

NAFLD · MASH · NASH/MASH

Not yet recruiting NCT07713823

Study on the Construction and Application of a Large Model Corpus for Pancreatic Cancer Based on Real Clinical Cases

— Observational —

Pancreatic Cancer · Pancreatic Cancer Metastatic · Pancreatic Cancer Non-resectable

Recruiting NCT07281768

Capecitabine/Oxaliplatin Chemotherapy and Cemiplimab With or Without Fianlimab or REGN7075 in Locally Advanced Rectal Cancer

Phase II Interventional United States

Colorectal Cancer

Not yet recruiting NCT07690683

Patients With Hepatocellular Carcinoma (HCC)

No phase Interventional Italy

Hepatocellular Carcinoma · Hepatocellular Cancer · Liver Diseases

Recruiting NCT07717437

DRAGON Registry - International Multicenter Registry and Medical Image Bank for Patients With Primarily Unresectable Liver Cancer or Liver Metastases That Underwent Combined Portal and Hepatic Vein Embolization (PVE/HVE) to Increase Future Liver Remnant Before Resection.

— Observational United States, Australia +11

Liver Cancer · Liver Metastases

Recruiting NCT05868135

Effects and Cost-effectiveness of e-Meistring - a Guided Internet-delivered Psychological Treatment

— Observational Norway

Depression Moderate · Anxiety, Social · Panic Disorder

Not yet recruiting NCT07713472

Abdominal Massage After Colon Surgery for Cancer

No phase Interventional France

Colonic Cancer

Recruiting NCT07713433

Oral Antibiotics vs. No Antibiotics in Pediatric Colorectal Surgery

No phase Interventional Pakistan

Bowel Cleansing Prior to Clinical Procedures · Colorectal Anastomosis

Recruiting NCT04929223

A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

Phase I Interventional United States, Australia +9

Metastatic Colorectal Cancer

Recruiting NCT07714902

Administration Of Calcium Gluconate for The Reduction of Blood Loss During Vaginal Delivery

No phase Interventional Israel

Postpartum Hemorrhage

Recruiting NCT03862781

Intra-Corporeal Anastomosis Result in Quicker Return of Bowel Function/Earlier Discharge

No phase Interventional United States

Colorectal Disorders

Not yet recruiting NCT07714941

EUS-Guided ATI and SWE in Individuals With Normal FibroScan

— Observational India

Non-hepatobiliary Indications

Recruiting NCT04545957

Jump: MR Simulation For Radiation Therapy Master Protocol

No phase Interventional United States

Prostate Cancer · Recurrent Adenocarcinoma · Liver Cancer

Recruiting NCT04781322

Safety, Tolerability, and Bioeffects of Alirocumab in Non-treatment Seeking Heavy Drinkers

Phase I Interventional United States

Alcohol Associated Liver Disease · Heavy Drinking Behavior

Recruiting NCT07715500

Magnetic Resonance Cholangiopancreatography in Living Liver Donors and Its Relationship With Post Operative Recipient Biliary Complications

No phase Interventional India

Chronic Liver Disease and Cirrhosis · Liver Transplant; Complications · Donor Hepatectomy

Recruiting NCT06907342

Testing a Functional Precision Medicine Approach to Select Chemotherapy for Metastatic Colorectal Cancer (COSENSE-1)

Phase II Interventional Norway

Tumor, Colorectal · Organoids · Tumoroid

Recruiting NCT07692204

A Dose Optimization/Expansion Study of SAR445877 in Adult Chinese Participants With Advanced Gastric or Gastroesophageal Junction Cancer

Phase II Interventional China

Gastric Cancer · Oesophageal Carcinoma

Recruiting NCT07625657

CLIKX® Tympanostomy Tube Delivery System for the Placement of Tympanostomy Tubes

No phase Interventional United States

Otitis Media · Otitis Media Chronic · Otitis Media Effusion

Recruiting NCT05015296

The Impact of Immune Cell Changes During the Perioperative Period on the Prognosis of Patients With Colorectal Cancer

— Observational China

Colorectal Cancer

Enrolling by invitation NCT07707778

Tirzepatide's Effects on Epigenetic Aging and Metabolic Restoration in Virally Suppressed People With HIV

Phase IV Interventional Taiwan

Human Immunodeficiency Virus (HIV) · Metabolic Dysfunction Associated Steatotic Liver Disease · Dyslipidaemia

Not yet recruiting NCT07713992

Efficacy and Safety of Mazdutide in Patients With Type 2 Diabetes Mellitus and Moderate to Severe Nonalcoholic Fatty Liver Disease Previously Treated With Semaglutide

No phase Interventional —

Type 2 Diabetes Mellitus (T2DM) · Nonalcoholic Fatty Liver Disease (NAFLD) With History of Diabetes Melitus

Recruiting NCT05248581

Living Donor Liver Transplant for Unresectable Colorectal Liver Metastases

— Observational United States

Colorectal Cancer Metastatic

Not yet recruiting NCT07714317

Phase Ib/II Multicenter Randomized Control Study of Peri-operative Treatment With Combination of CTLA-4, PD-1 Antibodies and Bevacizumab in Resectable HCC (Prophet)

Phase I / Phase II Interventional —

Resectable Hepatocellular Carcinoma

Recruiting NCT05849753

Breaking Disparities in Access to Advanced Diabetes Technologies in Children With Type 1 Diabetes

— Observational United States

Diabetes Mellitus, Type 1 · Child · Delivery of Health Care

Not yet recruiting NCT07715747

A Phase I Study to Evaluate the Safety,Pharmacokinetics,Pharmacodynamics,and Efficacy of TJ037130 in Adult Participants With Advanced Solid Tumors

Phase I Interventional China

Solid Tumor · Metastatic Ovary Cancer · Metastatic Gastric Cancer

Recruiting NCT04796818

An Investigational Scan (Intravoxel Incoherent Motion Diffusion Weighted Imaging) for the Evaluation of Colorectal Cancer Liver Metastases Treatment Response

No phase Interventional United States

Metastatic Colorectal Carcinoma · Metastatic Malignant Neoplasm in the Liver · Resectable Colorectal Carcinoma

Recruiting NCT07221253

A Study of Rilvegostomig or Durvalumab Plus Chemotherapy for First-Line Treatment of Biliary Tract Cancer (ARTEMIDE-Biliary02)

Phase III Interventional United States, Australia +17

Biliary Tract Cancer

Not yet recruiting NCT07713758

A Trial to Examine if Repinatrabit is Processed Differently in Adults With Reduced Liver or Kidney Function Compared to Adults With Normal Liver and Kidney Function

Phase I Interventional —

Phenylketonuria

Not yet recruiting NCT07214259

Intervention for Alcohol Use Disorder Recovery After Liver Transplantation

No phase Interventional United States

Liver Transplant Recipient · Alcohol Use Disorders (AUD)

Recruiting NCT07117032

Simulation-Free Celiac Plexus Pain Ablation Using Stereotactic Body Radiotherapy (SBRT) in Participants With Cancer-Related Celiac Pain

Phase I Interventional United States

Pancreatic Cancer · Retroperitoneal Pain Syndrome

Not yet recruiting NCT07713953

Pre-procedural Risk Score-Based Endoscopist Assignment for Pain Reduction in Unsedated Colonoscopy

No phase Interventional China

Colonoscopy Pain

Recruiting NCT07221149

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)

Phase II / Phase III Interventional United States, Argentina +18

Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma

Recruiting NCT06252753

Observational Study Protocol: LIVER-R

— Observational United States, Australia +20

Hepatobiliary Cancers

Recruiting NCT07607873

TRANsplantation vs reSECTion After Conversion Therapy for Initially Unresectable Colorectal Liver Metastases

No phase Interventional Italy

Colorectal Liver Metastases

Recruiting NCT06905054

Pharmacologic Approaches to Preventing Primary Sclerosing Cholangitis Recurrence After Liver Transplantation

Phase II Interventional United States

Primary Sclerosing Cholangitis · Liver Transplant, Complications · PSC

Recruiting NCT06051617

Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis

Phase III Interventional United States, Argentina +26

Primary Biliary Cholangitis

Recruiting NCT07703709

Colorectal Cancer Real-world Outcomes Study of Survival With Immunomodulator Plus Standard Anti-cancer Therapies

— Observational Taiwan

Survival , Tumor

Recruiting NCT06916585

Chinese Phase II Trail of AS1501 in Acute-on-chronic Liver Failure (ACLF) Patients

Phase II Interventional China

Acute-On-Chronic Liver Failure

Recruiting NCT07681050

Phosphate in Acute Pancreatitis

Phase II Interventional United States

Pancreatitis

Enrolling by invitation NCT07711912

POLAR-STUDY: Polish AntiReflux Study

— Observational Poland

Reflux Disease, Gastro-Esophageal

Recruiting NCT07710495

Exercise to Improve Outcomes in Pancreatic Cancer

No phase Interventional United Kingdom

Pancreas Adenocarcinoma (MSI-H) · Deconditioning

Not yet recruiting NCT07218328

Food is Medicine in Survivorship: Examining the Feasibility and Impact of a Scalable Food Delivery and Culinary Medicine Program (FoodiiS) Among Pediatric Cancer Survivors and Their Families

No phase Interventional United States

Pediatric Cancer

Not yet recruiting NCT07712614

A Comparison of Cosmos Rx Medication Adherence Platform vs. Pharmacy Fill Adherence Measures

No phase Interventional United States

GERD (Gastroesophageal Reflux Disease)

Not yet recruiting NCT07709767

Conversion Therapy With Retlirafusp Alfa Plus Chemotherapy in Gastric or Gastroesophageal Junction Adenocarcinoma

Phase II Interventional —

Gastric Adenocarcinoma · Gastroesophageal Junction Adenocarcinoma

Not yet recruiting NCT07711067

A Study Comparing Whole-Body Heat Treatment Plus Systemic Therapy to Systemic Therapy Alone, for Advanced Pancreatic Cancer

Phase II / Phase III Interventional Belgium, Spain

Pancreatic Ductal Adenocarcinoma (mPDAC) · Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)

Recruiting NCT06859840

LEAF (Liver Tumor dEtection And classiFication AI)

No phase Interventional China

Liver Malignancy

Recruiting NCT06581146

A Study to Check Liver Health in Boys With XLMTM, a Serious Genetic Muscle Condition

— Observational United States, Canada +1

X-Linked Myotubular Myopathy

Recruiting NCT06534359

Transpyloric Versus Gastric Feeding in Bronchopulmonary Dysplasia

No phase Interventional United States

Bronchopulmonary Dysplasia · Gastroesophageal Reflux

Recruiting NCT06337708

Smart Walk: A Culturally Tailored Smartphone-Delivered Physical Activity Intervention for African American Women

Phase II Interventional United States

Physical Activity · Exercise · Heart Diseases

Recruiting NCT06077981

Comparison of 0.4% Hyaluronic Acid Solution Versus Hydroxyethylamide Solution in Submucosal Endoscopic Resections

No phase Interventional Brazil

Esophageal Neoplasms · Endoscopic Mucosal Resection · Hyaluronic Acid

Recruiting NCT06990659

Outpatient Versus Inpatient Care Pathway for Intra-arterial Treatment of Primary Liver Cancer (CHOC)

No phase Interventional France

Hepato Cellular Carcinoma (HCC) · Intrahepatic Cholangiocarcinoma

Recruiting NCT06796803

Camrelizumab Combined With Rivoceranib and Hepatic Arterial Infusion Chemotherapy (HAIC) as Conversion Therapy for Potentially Resectable Hepatocellular Carcinoma(HCC)

Phase II / Phase III Interventional China

Potentially Resectable Hepatocellular Carcinoma

Recruiting NCT06386224

Internet-Delivered Pain Self-Management for Persons With Acute Recurrent and Chronic Pancreatitis Pain

No phase Interventional United States

Pancreatitis · Chronic Pancreatitis · Acute Recurrent Pancreatitis

Recruiting NCT06070376

Comparative Study Between (FC-SEMS) and (PC-SEMS) in the Palliation of Dysphagia Due to Malignant Neoplasm of Esophagus.

No phase Interventional Brazil

Esophageal Neoplasms · Dysphagia

Recruiting NCT07710885

Futibatinib (TAS-120) in Patients With Advanced Biliary Tract Cancer

Phase III Interventional Australia, Japan +2

Biliary Tract Cancer

Recruiting NCT07702799

Low-Residue Diet Versus Rectal Enema Before Laparoscopic Surgery for Endometrial Cancer

No phase Interventional Turkey (Türkiye)

Endometrial Cancer

Recruiting NCT07710807

Transperineal Versus Transrectal Cognitive Fusion Prostate Biopsy

No phase Interventional Turkey (Türkiye)

Prostate Cancer · Clinically Significant Prostate Cancer · Cognitive Fusion

Not yet recruiting NCT07708415

The Correlation of Postoperative Polyp Recurrence and Colorectal Cancer

— Observational China

Colorectal Cancer · Polyps

Recruiting NCT07487896

A Study of YL201 Versus Investigator's Choice of Chemotherapy in Participants With Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma After Failure of First-Line Therapy

Phase III Interventional China

Advanced Esophageal Squamous Cell Carcinoma

Recruiting NCT06840977

COLON ERDERLY LOW DOSE

— Observational Italy

Colon Adenocarcinoma

Recruiting NCT06948448

A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer

Phase II Interventional United States, Canada +4

Colorectal Cancer

Not yet recruiting NCT07707661

Application of Super-Resolution Ultrasound (SRUS) in Liver Tumor

— Observational —

Hepatocellular Carcinoma (HCC) · Intrahepatic Cholangiocellular Carcinoma · Hepatic Hemangioma

Recruiting NCT06439485

Phase I/II Trial of Pemigatinib in Combination With Atezolizumab and Bevacizumab for Treatment of Advanced Cholangiocarcinoma With FGFR2 Fusion

Phase I / Phase II Interventional United States

Advanced Cholangiocarcinoma · FGFR2 Fusion

Recruiting NCT07464756

SHR-1701 With or Without Apatinib in Combination With Chemotherapy as Neoadjuvant Therapy for Gastric Cancer

Phase II Interventional China

Gastric Adenocarcinoma

Recruiting NCT07707609

Neural Sensitisation and Neuropsychological Alterations in Painful Chronic Pancreatitis

— Observational India

Chronic Pancreatitis · Pain Management

Not yet recruiting NCT07708129

Repeat Late GDM Testing and Cesarean Delivery Rates

No phase Interventional —

Large for Gestational Age (LGA) · Pregnancy

Recruiting NCT06880835

Effect of Inhaled Technosphere Insulin vs RAA Insulin on Exercise-Induced Hypoglycemia in Adults With T1D Using Automated Insulin Delivery

No phase Interventional United States

Diabetes Mellitus, Type 1

Not yet recruiting NCT07686926

Becotatug Vedotin Plus Tislelizumab and Low-Dose Lenvatinib for Advanced Esophageal Squamous Cell Carcinoma, Phase II

Phase II Interventional —

Esophageal Squamous Cell Carcinoma

Recruiting NCT06927011

Chronic Loose Stools Following Right-sided Hemicolectomy for Colon Cancer and the Association With Bile Acid Malabsorption and Small Intestinal Bacterial Overgrowth Using a Novel Sampling Device

— Observational United States

Colon Cancer

Recruiting NCT07554456

A Study of BL-B01D1 in Combination With Tislelizumab ±5-Fluorouracil Versus Platinum-Based Chemotherapy Plus Tislelizumab as First-line Treatment in Patients With Unresectable, Locally Advanced Recurrent or Metastatic Esophageal Squamous Cell Carcinoma(PANKU-Esophagus02)

Phase II / Phase III Interventional China

Esophageal Squamous Cell Carcinoma

Recruiting NCT04524871

A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Advanced Liver Cancers (Morpheus-Liver)

Phase I / Phase II Interventional United States, China +5

Advanced Liver Cancers

Recruiting NCT05640791

Durvalumab Combined With Chemotherapy Neoadjuvant Therapy of Biliary Tract Cancer

Phase II Interventional China

Resectable Biliary Tract Cancer

Recruiting NCT07708116

First in Human Trial of CTX-187 in Healthy Volunteers and Chronically Infected Patients

Phase I Interventional Netherlands

Bronchiectasis Adult · Bronchiectasis With Pseudomonas Aeruginosa Colonization · Bacterial Infections

Not yet recruiting NCT07709429

Qigong Exercise for Muscles Strength and Quality of Life in Colorectal Cancer Patients Undergoing Chemotherapy

No phase Interventional Egypt

Colorectal Cancer

Recruiting NCT07709702

ERAS in Choledochal Cyst & Biliary Atresia

No phase Interventional Pakistan

Choledochal Cyst Resection · Biliary Atresia, Kasai Portoenterostomy Status

Recruiting NCT06235749

Administration Of Calcium Gluconate for The Reduction of Blood Loss During Elective Cesarean Delivery

No phase Interventional Israel

Elective Cesarean Delivery

Not yet recruiting NCT07707362

Improving Care Delivery for Patients With Mental Illness and Cancer Across a Cancer Center Network

No phase Interventional —

Cancer · Serious Mental Illness

Not yet recruiting NCT07709611

A Multicenter Clinical Study on Protein Absorption Efficiency in Patients With Pancreatic Exocrine Insufficiency in the ICU

Phase IV Interventional China

High-risk Patients With Pancreatic Exocrine Insufficiency · Enteral Nutrition Feeding

Not yet recruiting NCT07709533

An Umbrella-designed Prospective Multicenter Randomized Open-label Superiority Trial Evaluating Multi-biomarker-guided Precision Therapy for First-line Treatment of Advanced Esophageal Squamous Cell Carcinoma

Phase II Interventional China

Valid MeSH Conditions

Recruiting NCT05873699

Study Using Hyperpolarized 13C-Pyruvate Magnetic Resonance Spectroscopic Imaging in Patients With Pancreatic Cysts Undergoing Surgical Resection

Phase I Interventional United States

Pancreatic Cyst

Not yet recruiting NCT07709052

Predictive Biomarkers for Early Diagnosis of Pancreatic Ductal Adenocarcinoma (PDAC)

— Observational —

Pancreatic Ductal Adenocarcinoma (PDAC) · Intraductal Papillary Mucinous Neoplasm of Pancreas · Pancreatic Intraepithelial Neoplasia

Not yet recruiting NCT07707804

Bionic Balloon-assisted Delivery Technology on the Labor Process

No phase Interventional China

Vaginal Delivery

Enrolling by invitation NCT07140289

Effect of Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RA) on Gastric Emptying

— Observational United States

Gastric Emptying · Glucagon-Like Peptide-1 Receptor Agonists · Intermittent Fasting

Recruiting NCT07617610

Primary and Acquired Resistance to Targeted Treatment in BRAF V600E-mutated Metastatic Colorectal Cancer

— Observational Switzerland

Metastatic Colorectal Cancer · BRAF V600E Mutation

Recruiting NCT05092373

Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or Thorax

Phase I Interventional United States

Advanced Breast Carcinoma · Advanced Endometrial Carcinoma · Advanced Fallopian Tube Carcinoma

Recruiting NCT07708220

Laparoscopic Management of Gastroesophageal Reflux Disease in Children

No phase Interventional Egypt

Gastric Function Disorder

Not yet recruiting NCT07707505

Intracavernosal Exosomes vs. Rectal Ozone for Post-RARP Erectile Dysfunction

No phase Interventional Turkey (Türkiye)

Erectile Dysfunction Following Radical Prostatectomy

Recruiting NCT07189195

TR-002 for the Treatment of Advanced Unresectable Metastatic Solid Tumors Unresectable or Metastatic, Refractory Pancreatic Adenocarcinoma

Phase I Interventional United States

Advanced Malignant Solid Neoplasm · Metastatic Malignant Solid Neoplasm · Metastatic Pancreatic Adenocarcinoma

Enrolling by invitation NCT07708012

Clinical Study on Using Laparoscopic Sentinel Lymph Node Navigation Combined With Dual Endoscopy Surgery for Early Gastric Cancer

No phase Interventional China

Early-stage Upper Gastrointestinal Cancer · Stomach Cancer, Adenocarcinoma · Laparoscopy-assisted Surgery

Recruiting NCT07707531

A Study to Evaluate the Human Biodistribution and Dosimetry of the Radionuclide Labeled IR199 in Patients With Gastric Cancer and Pancreatic Cancer

Early Phase I Interventional China

Gastric Cancer · Pancreatic Cancer

Recruiting NCT07665710

Prediction of Pancreatogenic Diabetes After Partial Resection of the Pancreas

— Observational Slovenia

Pancreatogenic Diabetes Mellitus

Recruiting NCT06529523

Tislelizumab in People With Colorectal Cancer

Phase II Interventional United States, Nigeria

Colorectal Cancer

Recruiting NCT06388967

Pancreatic Cancer Detection Consortium

— Observational United States, Japan +1

Pancreatic Cancer · Pancreatic Carcinoma · Pancreatic Adenocarcinoma

Recruiting NCT06548412

CTX-009 With Gemcitabine, Cisplatin, and Durvalumab as First-line Therapy in Patients With Unresectable or Metastatic Biliary Tract Cancers

Phase I / Phase II Interventional United States

Metastatic Biliary Tract Cancer

Recruiting NCT07705139

The Value of Bowel Sounds in Evaluating Postoperative Intestinal Function Recovery in Colorectal Cancer Patients

— Observational China

Bowel Sounds · Colorectal Cancer · Intestinal Obstruction

Recruiting NCT07010497

A Prospective Study to Evaluate the Safety and Efficacy of the Combination Therapy of Irpagratinib, Atezolizumab, and Bevacizumab in Patients With Hepatocellular Carcinoma

Phase II Interventional South Korea

Carcinoma, Hepatocellular