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Not yet recruiting NCT07708415

The Correlation of Postoperative Polyp Recurrence and Colorectal Cancer

— Observational Colorectal Cancer Polyps

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Endoscopic polypectomy.
Who it may be relevant to
Registry conditions: Colorectal Cancer, Polyps. Basic parameters: 18 years — 80 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
China
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Postoperative Endoscopic Polyp Recurrence Correlation With Pathological Status Classification of Colorectal Cancer: a Multicenter, Retrospective Cohort Open-label Study

Overview

Postoperative endoscopic polyp recurrence correlation of colorectal cancer: a retrospective cohort open-label study

Detailed description

This study aims to address the gaps in existing research by focusing on the high-risk group of colorectal cancer patients post-radical surgery, systematically reviewing potential factors influencing polyp recurrence, further clarifying independent risk factors for postoperative polyp recurrence in this population, and constructing a predictive model that better aligns with the clinical needs of such patients, thereby providing more precise references for developing personalized follow-up strategies in clinical practice.

Interventions

  • Procedure Endoscopic polypectomy
    Endoscopic polypectomy

Primary outcome measures

  • Adenoma recurrence after colorectal surgery [Time frame: Postoperative；follow up till 5 years]
  • Colitisafter colorectal surgery [Time frame: Postoperative；follow up till 5 years]

Eligibility criteria

Inclusion criteria

Patients who underwent radical surgery for colon cancer at Gansu Provincial People's Hospital from January 2015 to December 2024 and regularly completed colonoscopy follow-up after surgery were selected as the research subjects. Inclusion criteria:

Diagnosed with colon cancer through histopathological examination ; Undergoing radical R0 resection ； Complete Colonoscopy follow-up after surgery less than 12 months.

Exclusion criteria

With adenomatous polyposis , Lynch syndrome and Peutz-Jeghers syndrome； Combined inflammatory bowel disease; Polyp were present before surgery and have not been completely removed； With distant metastasis or local recurrence； Clinical data is missing and can not be analyzed.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

China · 1 center
  • Gansu provincial hospital — Lanzhou

Publications

  • Galjart B, Hoppener DJ, Aerts JGJV, Bangma CH, Verhoef C, Grunhagen DJ. Follow-up strategy and survival for five common cancers: A meta-analysis. Eur J Cancer. 2022 Oct;174:185-199. doi: 10.1016/j.ejca.2022.07.025. Epub 2022 Aug 27. PMID 36037595
  • IJspeert JEG, Bretthauer M, Jover R, Dekker E; Dutch colonoscopy surveillance working group. Balancing benefit and burden: rethinking post-polypectomy colonoscopy surveillance strategies. Lancet Gastroenterol Hepatol. 2026 Aug;11(8):720-726. doi: 10.1016/S2468-1253(26)00128-7. Epub 2026 Jun 19. PMID 42320508
  • Ebert MP, Reichermeier S, Klug L, Lynen Jansen P, Pox C. Clinical Practice Guideline: Colorectal Cancer-Diagnosis, Treatment, Prevention, and Long-Term Follow-Up Care. Dtsch Arztebl Int. 2025 Dec 26;122(26):729-734. doi: 10.3238/arztebl.m2025.0196. Epub 2025 Dec 26. PMID 41195479
  • Laven-Law G, Symonds EL, Simpson K, Coats M, De Silva M, Hollington P, Cock C, Wassie MM. Risk of Advanced Colorectal Neoplasia at Follow-up Colonoscopy After Synchronous Adenoma and Clinically Significant Serrated Polyp. Clin Gastroenterol Hepatol. 2026 Feb;24(2):544-553. doi: 10.1016/j.cgh.2025.07.023. Epub 2025 Aug 5. PMID 40774589

Identifiers

NCT: NCT07708415 · Colorectal cancer and polyp

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗